Drugs: Pt I and II
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| AMPT | TH inhibitor
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| reserpine | VMAT2 inhibitor
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| apomorphine | direct DA receptor agonist
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| amphetamine | indirect DA receptor agonist
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| propanolol | B1/B2 receptor blocker
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| atenolol | B1 receptor blocker
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| phentolamine | a1/a2 blocker
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| prazosin | a1 blocker
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| haloperidol | D2/D3 blocker, treats mania and depression
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| SCH-22390 | D1 blocker
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| raclopride | D2 blocker
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| cocaine | inhibits CA and 5-HT reuptake and stimulates D1 receptors to induce locomotion in rats
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| desipramine | CA reuptake inhibitor
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| nortriptyline | CA reuptake inhibitor
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| ropinirol | DA receptor agonist
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| phenelzine | MAO inhibitor
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| 6-OHDA | Destroys DA neurons
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| hemicholinium-3 | inhibits choline uptake causing exponential decrease in Ach levels
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| vesamicol | VAchT inhibitor
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| botulinum toxin | inhibition of Ach release via proteolytic cleavage of synaptobrevin
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| alpha-latrotoxin | increases Ca2+ entry and Ach release and causes salivation and ab muscle cramping
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| curare | nicotinic receptor blocker; NO CNS entry
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| mecamylamine | nicotinic receptor blocker; CNS entry
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| atropine | muscarinic receptor blocker; CNS entry
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| scopolamine | muscarinic receptor blocker; CNS entry
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| methscopolamine | muscarinic receptor blocker; NO CNS entry
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| 2-PAM | regenerates AchE
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| endrophonium (Tensilon) | short acting AchE inhibitor used to diagnose myasthenia gravis
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| neostigimine | AchE inhibitor; NO CNS entry
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| physostigimine | AchE inhibitor; CNS entry
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| aricept | AchE inhibitor; CNS entry, used to treat Alzheimer's
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| PCPA | inhibits tryptophan hydroxylase (which decreases 5-HT synthesis)
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| fenfluramine | stimulates 5-HT release and inhibits reuptake
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| MDMA | stimulates 5-HT release and causes nerve damage in the neocortex of squirrel monkeys
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| busipirone | 5-HT1A agonist used to treat anxiety
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| sumatriptan | 5-HT1D agonist used to treat migraines
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| ketanserin | 5-HT2 blocker that antagonizes LSD induced motor effects
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| odansetron | 5-HT3 antagonist that is used as an antiemetic for cancer patients
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| amitriptyline | tricyclic antidepressant that inhibits 5-HT reuptake
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| fluoxetine (Prozac) | SSRI and antidepressant
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| setraline (Zoloft) | SSRI and antidepressant
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| 5,7-DHT | selectively destroys 5-HT neurons
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| thiosemicarbazide | inhibits GAD which inhibits GABA synthesis
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| tetanus toxin | inhibits GABA release
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| muscimol | GABA agonist that produces hallucinations
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| barbiturates (pentobarbital/nembutal) | increase duration of Cl- channel opening and are used as anti-epileptics
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| benzodiazepines | increase frequency of Cl- channel opening and are used as anti-anxiety and anti-epileptic drugs
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| diazepam binding inhibitor (DBI) | opposite effect of BDZ's, producing anxiety
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| RO15-4513 | alcohol antagonist that blocks the effect of ethanol on Cl- permeability and blocks the ataxic effects of alcohol
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| allopregnanolone | GABAa potentiator and neurosteroid
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| bicuculline | competitive GABAa antagonist
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| pentylenetetrazol (metrazole) | noncompetitive GABAa antagonist used to create seizures in lab animals
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| baclofen | GABAb agonist used as muscle relaxant
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| phaclofen | GABAb antagonist
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| tiagabine | GAT-1 inhibitor used as antiepileptic
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| vigabatrin | inhibits GABA-T and is used as antiepileptic
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| GABA-T | converts GABA to succinate
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| cocaine | inhibits CA and 5-HT reuptake
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| morphine | stimulates opiate receptors
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| marijuana | stimulates cannabinoid receptors
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| LSD/psilocybin | stimulate 5-HT receptors; LSD=5-HT2
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| alcohol | potentiation of GABA receptors
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| naltrexone | opiate antagonist that might help to treat alcoholism
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| bromocriptine | DA receptor agonist
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| methadone | opiate receptor agonist used to treat addicts
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| buprenorphine | partial agonist at opiate receptors
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| SB-277011-A | D3 receptor antagonist
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| rimonabant (Acomplia/SR141716) | CB1 receptor antagonist
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| disulfiram (antabuse) | cause buildup of acetaldehyde if alcohol is consumed and is used to treat alcoholism
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| abstem (tempsoil) | cause buildup of acetaldehyde if alcohol is consumed and is used to treat alcoholism
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| acamprosate (campral) | activation of GABAb receptors and inhibition of glu release. Also prevents increase in glu from withdrawal
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| oxymorphine | opiate receptor agonist
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| naloxone | opiate receptor antagonist
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| enkephalin | NT which inhibits primary sensory afferent pain neurons from sending a signal to the spinal cord; can be considered an endogenous opiate
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| nalmefene | opiate receptor antagonist
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| LAAM | opiate agonist
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| BP 897 | DA partial agonist that inhibits cocaine reinforcement
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| methylphenidate (Ritalin) | amphetamine related compound that treats ADHD
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| R-PIA | A1 agonist
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| NECA | A2 agonist
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| DMPX | A2 antagonist
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| pentolinium | nicotinic receptor antagonist; NO CNS entry
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| bupropion (Zyban) | sustained release tablets used to quit smoking and treat depression. Reuptake inhibitor of CAs and 5-HT
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| marinol | appetite stimulant
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| cannador | THC+cannabinoids; antispasmodic under testing
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| anandamide, 2-AG | endocannabinoids
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| D-cycloserine | partial agonist at glycine site on NMDA receptor
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| nitrous oxide | "laughing gas"
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| toluene | inhalant
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| GHB | potentiation of direct activation of GABAb receptor that can produce sedation, analgesia and anterograde amnesia; used as a date rape drug and treat loss of muscle control in narcolepsy
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| flunitrazepam (Rohypnol) | date rape drug
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| CGP 35348 | GABAb antagonist
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| nandrolone and THG | anabolic steroids
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| iproniazid | MAO inhibitor that treated TB in 50's
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| imiparmine | tricyclic antidepressant
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| tranylcypromine | MAO inhibitor
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| lithium | May dampen PI second messenger system and cause behavioral stimulation. Used as long term bipolar treatment
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| NBQX | competitive kainate and AMPA antagonist
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| CPP | competitive NMDA antagonist
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| MK-801 | noncompetitive NMDA antagonist
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| PCP | noncompetitive NMDA antagonist
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| ketamine | noncompetitive NMDA antagonist
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| licostinel (ACEA1021) | competitive antagonist on glycine site of NMDA receptor
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| memantine | low affinity NMDA antagonist used to treat Alzheimer's
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