Drugs: Pt I and II Word Scramble
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| Question | Answer |
| AMPT | TH inhibitor |
| reserpine | VMAT2 inhibitor |
| apomorphine | direct DA receptor agonist |
| amphetamine | indirect DA receptor agonist |
| propanolol | B1/B2 receptor blocker |
| atenolol | B1 receptor blocker |
| phentolamine | a1/a2 blocker |
| prazosin | a1 blocker |
| haloperidol | D2/D3 blocker, treats mania and depression |
| SCH-22390 | D1 blocker |
| raclopride | D2 blocker |
| cocaine | inhibits CA and 5-HT reuptake and stimulates D1 receptors to induce locomotion in rats |
| desipramine | CA reuptake inhibitor |
| nortriptyline | CA reuptake inhibitor |
| ropinirol | DA receptor agonist |
| phenelzine | MAO inhibitor |
| 6-OHDA | Destroys DA neurons |
| hemicholinium-3 | inhibits choline uptake causing exponential decrease in Ach levels |
| vesamicol | VAchT inhibitor |
| botulinum toxin | inhibition of Ach release via proteolytic cleavage of synaptobrevin |
| alpha-latrotoxin | increases Ca2+ entry and Ach release and causes salivation and ab muscle cramping |
| curare | nicotinic receptor blocker; NO CNS entry |
| mecamylamine | nicotinic receptor blocker; CNS entry |
| atropine | muscarinic receptor blocker; CNS entry |
| scopolamine | muscarinic receptor blocker; CNS entry |
| methscopolamine | muscarinic receptor blocker; NO CNS entry |
| 2-PAM | regenerates AchE |
| endrophonium (Tensilon) | short acting AchE inhibitor used to diagnose myasthenia gravis |
| neostigimine | AchE inhibitor; NO CNS entry |
| physostigimine | AchE inhibitor; CNS entry |
| aricept | AchE inhibitor; CNS entry, used to treat Alzheimer's |
| PCPA | inhibits tryptophan hydroxylase (which decreases 5-HT synthesis) |
| fenfluramine | stimulates 5-HT release and inhibits reuptake |
| MDMA | stimulates 5-HT release and causes nerve damage in the neocortex of squirrel monkeys |
| busipirone | 5-HT1A agonist used to treat anxiety |
| sumatriptan | 5-HT1D agonist used to treat migraines |
| ketanserin | 5-HT2 blocker that antagonizes LSD induced motor effects |
| odansetron | 5-HT3 antagonist that is used as an antiemetic for cancer patients |
| amitriptyline | tricyclic antidepressant that inhibits 5-HT reuptake |
| fluoxetine (Prozac) | SSRI and antidepressant |
| setraline (Zoloft) | SSRI and antidepressant |
| 5,7-DHT | selectively destroys 5-HT neurons |
| thiosemicarbazide | inhibits GAD which inhibits GABA synthesis |
| tetanus toxin | inhibits GABA release |
| muscimol | GABA agonist that produces hallucinations |
| barbiturates (pentobarbital/nembutal) | increase duration of Cl- channel opening and are used as anti-epileptics |
| benzodiazepines | increase frequency of Cl- channel opening and are used as anti-anxiety and anti-epileptic drugs |
| diazepam binding inhibitor (DBI) | opposite effect of BDZ's, producing anxiety |
| RO15-4513 | alcohol antagonist that blocks the effect of ethanol on Cl- permeability and blocks the ataxic effects of alcohol |
| allopregnanolone | GABAa potentiator and neurosteroid |
| bicuculline | competitive GABAa antagonist |
| pentylenetetrazol (metrazole) | noncompetitive GABAa antagonist used to create seizures in lab animals |
| baclofen | GABAb agonist used as muscle relaxant |
| phaclofen | GABAb antagonist |
| tiagabine | GAT-1 inhibitor used as antiepileptic |
| vigabatrin | inhibits GABA-T and is used as antiepileptic |
| GABA-T | converts GABA to succinate |
| cocaine | inhibits CA and 5-HT reuptake |
| morphine | stimulates opiate receptors |
| marijuana | stimulates cannabinoid receptors |
| LSD/psilocybin | stimulate 5-HT receptors; LSD=5-HT2 |
| alcohol | potentiation of GABA receptors |
| naltrexone | opiate antagonist that might help to treat alcoholism |
| bromocriptine | DA receptor agonist |
| methadone | opiate receptor agonist used to treat addicts |
| buprenorphine | partial agonist at opiate receptors |
| SB-277011-A | D3 receptor antagonist |
| rimonabant (Acomplia/SR141716) | CB1 receptor antagonist |
| disulfiram (antabuse) | cause buildup of acetaldehyde if alcohol is consumed and is used to treat alcoholism |
| abstem (tempsoil) | cause buildup of acetaldehyde if alcohol is consumed and is used to treat alcoholism |
| acamprosate (campral) | activation of GABAb receptors and inhibition of glu release. Also prevents increase in glu from withdrawal |
| oxymorphine | opiate receptor agonist |
| naloxone | opiate receptor antagonist |
| enkephalin | NT which inhibits primary sensory afferent pain neurons from sending a signal to the spinal cord; can be considered an endogenous opiate |
| nalmefene | opiate receptor antagonist |
| LAAM | opiate agonist |
| BP 897 | DA partial agonist that inhibits cocaine reinforcement |
| methylphenidate (Ritalin) | amphetamine related compound that treats ADHD |
| R-PIA | A1 agonist |
| NECA | A2 agonist |
| DMPX | A2 antagonist |
| pentolinium | nicotinic receptor antagonist; NO CNS entry |
| bupropion (Zyban) | sustained release tablets used to quit smoking and treat depression. Reuptake inhibitor of CAs and 5-HT |
| marinol | appetite stimulant |
| cannador | THC+cannabinoids; antispasmodic under testing |
| anandamide, 2-AG | endocannabinoids |
| D-cycloserine | partial agonist at glycine site on NMDA receptor |
| nitrous oxide | "laughing gas" |
| toluene | inhalant |
| GHB | potentiation of direct activation of GABAb receptor that can produce sedation, analgesia and anterograde amnesia; used as a date rape drug and treat loss of muscle control in narcolepsy |
| flunitrazepam (Rohypnol) | date rape drug |
| CGP 35348 | GABAb antagonist |
| nandrolone and THG | anabolic steroids |
| iproniazid | MAO inhibitor that treated TB in 50's |
| imiparmine | tricyclic antidepressant |
| tranylcypromine | MAO inhibitor |
| lithium | May dampen PI second messenger system and cause behavioral stimulation. Used as long term bipolar treatment |
| NBQX | competitive kainate and AMPA antagonist |
| CPP | competitive NMDA antagonist |
| MK-801 | noncompetitive NMDA antagonist |
| PCP | noncompetitive NMDA antagonist |
| ketamine | noncompetitive NMDA antagonist |
| licostinel (ACEA1021) | competitive antagonist on glycine site of NMDA receptor |
| memantine | low affinity NMDA antagonist used to treat Alzheimer's |
Created by:
brienne.donovan
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