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Drugs: Pt I and II
Question | Answer |
---|---|
AMPT | TH inhibitor |
reserpine | VMAT2 inhibitor |
apomorphine | direct DA receptor agonist |
amphetamine | indirect DA receptor agonist |
propanolol | B1/B2 receptor blocker |
atenolol | B1 receptor blocker |
phentolamine | a1/a2 blocker |
prazosin | a1 blocker |
haloperidol | D2/D3 blocker, treats mania and depression |
SCH-22390 | D1 blocker |
raclopride | D2 blocker |
cocaine | inhibits CA and 5-HT reuptake and stimulates D1 receptors to induce locomotion in rats |
desipramine | CA reuptake inhibitor |
nortriptyline | CA reuptake inhibitor |
ropinirol | DA receptor agonist |
phenelzine | MAO inhibitor |
6-OHDA | Destroys DA neurons |
hemicholinium-3 | inhibits choline uptake causing exponential decrease in Ach levels |
vesamicol | VAchT inhibitor |
botulinum toxin | inhibition of Ach release via proteolytic cleavage of synaptobrevin |
alpha-latrotoxin | increases Ca2+ entry and Ach release and causes salivation and ab muscle cramping |
curare | nicotinic receptor blocker; NO CNS entry |
mecamylamine | nicotinic receptor blocker; CNS entry |
atropine | muscarinic receptor blocker; CNS entry |
scopolamine | muscarinic receptor blocker; CNS entry |
methscopolamine | muscarinic receptor blocker; NO CNS entry |
2-PAM | regenerates AchE |
endrophonium (Tensilon) | short acting AchE inhibitor used to diagnose myasthenia gravis |
neostigimine | AchE inhibitor; NO CNS entry |
physostigimine | AchE inhibitor; CNS entry |
aricept | AchE inhibitor; CNS entry, used to treat Alzheimer's |
PCPA | inhibits tryptophan hydroxylase (which decreases 5-HT synthesis) |
fenfluramine | stimulates 5-HT release and inhibits reuptake |
MDMA | stimulates 5-HT release and causes nerve damage in the neocortex of squirrel monkeys |
busipirone | 5-HT1A agonist used to treat anxiety |
sumatriptan | 5-HT1D agonist used to treat migraines |
ketanserin | 5-HT2 blocker that antagonizes LSD induced motor effects |
odansetron | 5-HT3 antagonist that is used as an antiemetic for cancer patients |
amitriptyline | tricyclic antidepressant that inhibits 5-HT reuptake |
fluoxetine (Prozac) | SSRI and antidepressant |
setraline (Zoloft) | SSRI and antidepressant |
5,7-DHT | selectively destroys 5-HT neurons |
thiosemicarbazide | inhibits GAD which inhibits GABA synthesis |
tetanus toxin | inhibits GABA release |
muscimol | GABA agonist that produces hallucinations |
barbiturates (pentobarbital/nembutal) | increase duration of Cl- channel opening and are used as anti-epileptics |
benzodiazepines | increase frequency of Cl- channel opening and are used as anti-anxiety and anti-epileptic drugs |
diazepam binding inhibitor (DBI) | opposite effect of BDZ's, producing anxiety |
RO15-4513 | alcohol antagonist that blocks the effect of ethanol on Cl- permeability and blocks the ataxic effects of alcohol |
allopregnanolone | GABAa potentiator and neurosteroid |
bicuculline | competitive GABAa antagonist |
pentylenetetrazol (metrazole) | noncompetitive GABAa antagonist used to create seizures in lab animals |
baclofen | GABAb agonist used as muscle relaxant |
phaclofen | GABAb antagonist |
tiagabine | GAT-1 inhibitor used as antiepileptic |
vigabatrin | inhibits GABA-T and is used as antiepileptic |
GABA-T | converts GABA to succinate |
cocaine | inhibits CA and 5-HT reuptake |
morphine | stimulates opiate receptors |
marijuana | stimulates cannabinoid receptors |
LSD/psilocybin | stimulate 5-HT receptors; LSD=5-HT2 |
alcohol | potentiation of GABA receptors |
naltrexone | opiate antagonist that might help to treat alcoholism |
bromocriptine | DA receptor agonist |
methadone | opiate receptor agonist used to treat addicts |
buprenorphine | partial agonist at opiate receptors |
SB-277011-A | D3 receptor antagonist |
rimonabant (Acomplia/SR141716) | CB1 receptor antagonist |
disulfiram (antabuse) | cause buildup of acetaldehyde if alcohol is consumed and is used to treat alcoholism |
abstem (tempsoil) | cause buildup of acetaldehyde if alcohol is consumed and is used to treat alcoholism |
acamprosate (campral) | activation of GABAb receptors and inhibition of glu release. Also prevents increase in glu from withdrawal |
oxymorphine | opiate receptor agonist |
naloxone | opiate receptor antagonist |
enkephalin | NT which inhibits primary sensory afferent pain neurons from sending a signal to the spinal cord; can be considered an endogenous opiate |
nalmefene | opiate receptor antagonist |
LAAM | opiate agonist |
BP 897 | DA partial agonist that inhibits cocaine reinforcement |
methylphenidate (Ritalin) | amphetamine related compound that treats ADHD |
R-PIA | A1 agonist |
NECA | A2 agonist |
DMPX | A2 antagonist |
pentolinium | nicotinic receptor antagonist; NO CNS entry |
bupropion (Zyban) | sustained release tablets used to quit smoking and treat depression. Reuptake inhibitor of CAs and 5-HT |
marinol | appetite stimulant |
cannador | THC+cannabinoids; antispasmodic under testing |
anandamide, 2-AG | endocannabinoids |
D-cycloserine | partial agonist at glycine site on NMDA receptor |
nitrous oxide | "laughing gas" |
toluene | inhalant |
GHB | potentiation of direct activation of GABAb receptor that can produce sedation, analgesia and anterograde amnesia; used as a date rape drug and treat loss of muscle control in narcolepsy |
flunitrazepam (Rohypnol) | date rape drug |
CGP 35348 | GABAb antagonist |
nandrolone and THG | anabolic steroids |
iproniazid | MAO inhibitor that treated TB in 50's |
imiparmine | tricyclic antidepressant |
tranylcypromine | MAO inhibitor |
lithium | May dampen PI second messenger system and cause behavioral stimulation. Used as long term bipolar treatment |
NBQX | competitive kainate and AMPA antagonist |
CPP | competitive NMDA antagonist |
MK-801 | noncompetitive NMDA antagonist |
PCP | noncompetitive NMDA antagonist |
ketamine | noncompetitive NMDA antagonist |
licostinel (ACEA1021) | competitive antagonist on glycine site of NMDA receptor |
memantine | low affinity NMDA antagonist used to treat Alzheimer's |