Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Drugs: Pt I and II
| Question | Answer |
|---|---|
| AMPT | TH inhibitor |
| reserpine | VMAT2 inhibitor |
| apomorphine | direct DA receptor agonist |
| amphetamine | indirect DA receptor agonist |
| propanolol | B1/B2 receptor blocker |
| atenolol | B1 receptor blocker |
| phentolamine | a1/a2 blocker |
| prazosin | a1 blocker |
| haloperidol | D2/D3 blocker, treats mania and depression |
| SCH-22390 | D1 blocker |
| raclopride | D2 blocker |
| cocaine | inhibits CA and 5-HT reuptake and stimulates D1 receptors to induce locomotion in rats |
| desipramine | CA reuptake inhibitor |
| nortriptyline | CA reuptake inhibitor |
| ropinirol | DA receptor agonist |
| phenelzine | MAO inhibitor |
| 6-OHDA | Destroys DA neurons |
| hemicholinium-3 | inhibits choline uptake causing exponential decrease in Ach levels |
| vesamicol | VAchT inhibitor |
| botulinum toxin | inhibition of Ach release via proteolytic cleavage of synaptobrevin |
| alpha-latrotoxin | increases Ca2+ entry and Ach release and causes salivation and ab muscle cramping |
| curare | nicotinic receptor blocker; NO CNS entry |
| mecamylamine | nicotinic receptor blocker; CNS entry |
| atropine | muscarinic receptor blocker; CNS entry |
| scopolamine | muscarinic receptor blocker; CNS entry |
| methscopolamine | muscarinic receptor blocker; NO CNS entry |
| 2-PAM | regenerates AchE |
| endrophonium (Tensilon) | short acting AchE inhibitor used to diagnose myasthenia gravis |
| neostigimine | AchE inhibitor; NO CNS entry |
| physostigimine | AchE inhibitor; CNS entry |
| aricept | AchE inhibitor; CNS entry, used to treat Alzheimer's |
| PCPA | inhibits tryptophan hydroxylase (which decreases 5-HT synthesis) |
| fenfluramine | stimulates 5-HT release and inhibits reuptake |
| MDMA | stimulates 5-HT release and causes nerve damage in the neocortex of squirrel monkeys |
| busipirone | 5-HT1A agonist used to treat anxiety |
| sumatriptan | 5-HT1D agonist used to treat migraines |
| ketanserin | 5-HT2 blocker that antagonizes LSD induced motor effects |
| odansetron | 5-HT3 antagonist that is used as an antiemetic for cancer patients |
| amitriptyline | tricyclic antidepressant that inhibits 5-HT reuptake |
| fluoxetine (Prozac) | SSRI and antidepressant |
| setraline (Zoloft) | SSRI and antidepressant |
| 5,7-DHT | selectively destroys 5-HT neurons |
| thiosemicarbazide | inhibits GAD which inhibits GABA synthesis |
| tetanus toxin | inhibits GABA release |
| muscimol | GABA agonist that produces hallucinations |
| barbiturates (pentobarbital/nembutal) | increase duration of Cl- channel opening and are used as anti-epileptics |
| benzodiazepines | increase frequency of Cl- channel opening and are used as anti-anxiety and anti-epileptic drugs |
| diazepam binding inhibitor (DBI) | opposite effect of BDZ's, producing anxiety |
| RO15-4513 | alcohol antagonist that blocks the effect of ethanol on Cl- permeability and blocks the ataxic effects of alcohol |
| allopregnanolone | GABAa potentiator and neurosteroid |
| bicuculline | competitive GABAa antagonist |
| pentylenetetrazol (metrazole) | noncompetitive GABAa antagonist used to create seizures in lab animals |
| baclofen | GABAb agonist used as muscle relaxant |
| phaclofen | GABAb antagonist |
| tiagabine | GAT-1 inhibitor used as antiepileptic |
| vigabatrin | inhibits GABA-T and is used as antiepileptic |
| GABA-T | converts GABA to succinate |
| cocaine | inhibits CA and 5-HT reuptake |
| morphine | stimulates opiate receptors |
| marijuana | stimulates cannabinoid receptors |
| LSD/psilocybin | stimulate 5-HT receptors; LSD=5-HT2 |
| alcohol | potentiation of GABA receptors |
| naltrexone | opiate antagonist that might help to treat alcoholism |
| bromocriptine | DA receptor agonist |
| methadone | opiate receptor agonist used to treat addicts |
| buprenorphine | partial agonist at opiate receptors |
| SB-277011-A | D3 receptor antagonist |
| rimonabant (Acomplia/SR141716) | CB1 receptor antagonist |
| disulfiram (antabuse) | cause buildup of acetaldehyde if alcohol is consumed and is used to treat alcoholism |
| abstem (tempsoil) | cause buildup of acetaldehyde if alcohol is consumed and is used to treat alcoholism |
| acamprosate (campral) | activation of GABAb receptors and inhibition of glu release. Also prevents increase in glu from withdrawal |
| oxymorphine | opiate receptor agonist |
| naloxone | opiate receptor antagonist |
| enkephalin | NT which inhibits primary sensory afferent pain neurons from sending a signal to the spinal cord; can be considered an endogenous opiate |
| nalmefene | opiate receptor antagonist |
| LAAM | opiate agonist |
| BP 897 | DA partial agonist that inhibits cocaine reinforcement |
| methylphenidate (Ritalin) | amphetamine related compound that treats ADHD |
| R-PIA | A1 agonist |
| NECA | A2 agonist |
| DMPX | A2 antagonist |
| pentolinium | nicotinic receptor antagonist; NO CNS entry |
| bupropion (Zyban) | sustained release tablets used to quit smoking and treat depression. Reuptake inhibitor of CAs and 5-HT |
| marinol | appetite stimulant |
| cannador | THC+cannabinoids; antispasmodic under testing |
| anandamide, 2-AG | endocannabinoids |
| D-cycloserine | partial agonist at glycine site on NMDA receptor |
| nitrous oxide | "laughing gas" |
| toluene | inhalant |
| GHB | potentiation of direct activation of GABAb receptor that can produce sedation, analgesia and anterograde amnesia; used as a date rape drug and treat loss of muscle control in narcolepsy |
| flunitrazepam (Rohypnol) | date rape drug |
| CGP 35348 | GABAb antagonist |
| nandrolone and THG | anabolic steroids |
| iproniazid | MAO inhibitor that treated TB in 50's |
| imiparmine | tricyclic antidepressant |
| tranylcypromine | MAO inhibitor |
| lithium | May dampen PI second messenger system and cause behavioral stimulation. Used as long term bipolar treatment |
| NBQX | competitive kainate and AMPA antagonist |
| CPP | competitive NMDA antagonist |
| MK-801 | noncompetitive NMDA antagonist |
| PCP | noncompetitive NMDA antagonist |
| ketamine | noncompetitive NMDA antagonist |
| licostinel (ACEA1021) | competitive antagonist on glycine site of NMDA receptor |
| memantine | low affinity NMDA antagonist used to treat Alzheimer's |
Created by:
brienne.donovan
Popular Neuroscience sets