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Pharm-Antifungals

Antifungals

QuestionAnswer
What are the 2 most common fungal infections discussed in class? Dermatophytes (ringworm) and Malassezia sp. (yeast)
Which fungal infection presents with circular skin lesions and is zoonotic? Dermatophytes (ringworm)
How would you diagnose a fungal infection? Clinical signs, skin scrapings, Wood's Lamp, fungal culture, ear smear
What drug is the first choice for ringworm infections? Dosage form? Itraconazole; Oral
What is a Cheaper alternative to Itraconazole? Fluconazole (Diflucan)
What form is it seen in and organism does it treat: Nystatin (Panalog/Anamax), Clotrimazole (Otomax) and Miconazole (Malaseb)? Topical/yeast
What organism does Ketoconazole treat? Dermatophytes (ringworm)
Superficial or Systemic Tx? Itraconazole Amphoteracin B Ketoconazole Griseofulvin Fluconozole/Diflucan Itraconazole - Both Amphoteracin B - Systemic Ketoconazole - Both Griseofulvin - Superficial Fluconozole/Diflucan - Superficial
Superficial or Systemic Tx? Nystatin/Panalog Flucytosine Clotrimazole/Otomax Miconazole/Malaseb Nystatin/Panalog - Superficial Flucytosine - Systemic Clotrimazole/Otomax - Superficial Miconazole/Malaseb - Superficial
What are the 4 types of systemic infections discussed in class? Blastomycosis, Histoplasmosis, Coccidiomycosis, Aspergillosis
What is the prognosis of cases of systemic fungal infections? Poor
What are some presenting symptomes of a systemic fungal infection? weight loss, dyspnea, chronic cough, lameness, skin lesions
How can systemic infections be transmitted? Is it zoonotic? inhalation or direct contact; yes
Rural and hunting dogs are at highest risk for what systemic fungal infection? Blastomycosis
Give 2 recommendations you would give a client treating ringworm in addition to drug therapy? Disinfect/destroy bedding; clip hair over infected areas to allow better penetration of medication to the skin; use antifungal shampoos; Vx are available for cats.
What is an important direction to tell the client when their animal is prescribed griseofulvin? Give with a fatty meal - increases absorption
What drug combination is commonly prescribed for Blastomycosis? Ketaconazole/Nizoral tabs and Amphotericin B
What organ is most affected by Amphotericin B? Kidneys
What drug works synergistically with Amphotericin B to treat Blastomycosis? Ketaconazole/Nizoral
How does one become infected with Blastomycosis? Inhaled from mold in the soil (sandy, acidic soils)
What organs does Blastomycosis affect? Lungs then through blood and lymph to eyes, brain, bone, lymph nodes, urogenital system, skin and SQ tissues
What organs does Histoplasmosis affect? Lungs
Where is Blastomycosis generally found? Upper midwest and Canada
Where is Histoplasmosis generally found? Southern states
Where does Histoplasmosis thrive? Soil enriched with bird or bat droppings
What organs does Coccidiomycosis affect? Lungs - esp. dogs
Where is Coccidiomycosis generally found? SW states, Mexico and S. America
Where does Aspergillosis thrive? Growing on dead leaves, stored grain, compost piles or other decaying vegetations (hen houses). Farms.
What organs does Aspergillosis affect? Respiratory, ears, liver, throat and mouth
What is the most common clinical symptom of aspergillosis? Sneezing blood and compulsively scratching snout/nose
Created by: k.jamie9