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APAP phases of tox

Tox lecture 6

PhaseTime following ingestionCharacteristics
II 24 to 36 hours Onset of liver injury with rise in AST/ALT
III 72 to 96 hours Maximal hepatotoxicity. Peak liver function abnormalities (PT/bili), peak liver enzymes (AST/ALT) Possible fulminant hepatic failure (encephalopathy, acidosis). Death 3-5 days.
IV 4 days to 2 weeks Resolution of hepatic dysfunction
I 0.5 to 24 hours Anorexia, nausea, vomiting, malaise, pallor, diaphoresis. Rare metabolic acidosis, coma
Created by: pberriochoa
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