Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Acetaminophen genera

Tox lecture 6

AcetaminophenAnswer
Absorption 30 – 60 minutes
Half-life: 1-3.5 hours
Metabolism/Excretion Renal unchanged acetaminophen Phase II: (Conjugation) sulfate/glucuronide conjugate Phase I: (CYP 2E1) conjugation with glutathione
Metabolism/Excretion Phase II: (Conjugation) sulfate/glucuronide conjugate
Metabolism/Excretion Renal unchanged acetaminophen
Metabolism/Excretion Phase I (CYP 2E1) conjugation with glutathione
Overdose Risk Factors Dose When history is reliable Increased frequency of APAP dosing Prolonged duration Increased capacity for CYP2E1 activation Decreased glutathione availability Decreased capacity for glucuronidation and/or sulfation
Impact in overdose Delayed absorption Saturation of normal non-toxic metabolic routes
Mechanism of Toxicity (see diagram in book) Normal metabolic pathway Not many drug interactions Note many things metabolized the same way
Mechanism of Toxicity (see diagram in book) Formation of toxic metabolite: A/-acetyl-p-benzoquinoneimine (NAPQI) RoleofCYP2E1 Importance of glutathione Local formation of NAPQI in tissues
Local formation of NAPQI in tissues Liver Kidneys Pancreas, heart, CNS
Other manifestations Early metabolic acidosis/coma Rule out other causes Associated with higher initial [APAP]? Uncommon
Other manifestations Renal function abnormalities -25% with significant hepatotoxicity
Other manifestations Rarely other manifestation Pancreatitis
Created by: pberriochoa
Popular Fitness sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards