lecture 15 sutor
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| 6 blood cell groups of greatest clinical significance | show 🗑
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| show | Ab is produced due to some dysregulation of pt's immune system, they attack Ag in pt's own body
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| alloantibody | show 🗑
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| show | Rh-D
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| blood group antigen most likely to cause Ab formation | show 🗑
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| show | alloantibodies like Rh, Duffy, etc - usually IgG /// anti-A and anti-B are usually IgM
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| show | ABO blood group incompatibilities
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| show | O-type pts make IgG class Abs, NOT IgM
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| show | usually occur from IgG class Abs like those in pts with O type blood or from Kidd Ag, cause extravascular hemolysis hours to days after transfusion, progressive anemia fever and discomfort noted
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| situations in which hemolytic dz of the newborn occurs | show 🗑
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| show | O --> she has pre-formed anti-A/B/AB of the IgG type that can cross the placenta
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| show | done with type and screen, looks for free RBC antibody in pt's plasma or serum. indicated for routine preg screening or work-up of autoimmune hemolysis
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| direct antiglobulin test (formerly the direct Coombs' test) | show 🗑
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| show | thus pre-formed Abs wouldn't have been detected for initial transfusion, but if they are given blood with the same Rh subtype there will be an ANAMNESTIC RESPONSE where on 2nd exposure Ab production is ramped up quickly = delayed hemolytic transfusion rxn
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Created by:
sirprakes
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