Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

PathofBloodGroups

lecture 15 sutor

QuestionAnswer
6 blood cell groups of greatest clinical significance ABO, Rh (C, c, D, E, e), Duffy (Fy-a, Fy-b), Kidd (Jk-a, Jk-b), Kell (K, k), MNSs (S, s most important)
autoantibody Ab is produced due to some dysregulation of pt's immune system, they attack Ag in pt's own body
alloantibody Ab produced against some foreign cell or substance that enters pt's body
most immunogenic blood group antigen Rh-D
blood group antigen most likely to cause Ab formation K of Kell
red cell alloantibodies of clinical significance are virtually always of the _______ class EXCEPT anti-A/B, which are of the _______ class alloantibodies like Rh, Duffy, etc - usually IgG /// anti-A and anti-B are usually IgM
which blood group interaction cause immediate intravascular hemolysis that usually results in death ABO blood group incompatibilities
anti-A/B antibodies in O blood type pt are of what Ig class? O-type pts make IgG class Abs, NOT IgM
delayed type hemolytic rxns usually occur from IgG class Abs like those in pts with O type blood or from Kidd Ag, cause extravascular hemolysis hours to days after transfusion, progressive anemia fever and discomfort noted
situations in which hemolytic dz of the newborn occurs mismatch in blood groups btwn mom and fetus with baby having at least one Ag mom doesn't, mother has made Ab previously, any IgG Ab that can cross placenta, any Ab that destructs fetal RBCs
blood type in mother that would be most concerning for hemolytic dz of newborn O --> she has pre-formed anti-A/B/AB of the IgG type that can cross the placenta
indirect antiglobulin test done with type and screen, looks for free RBC antibody in pt's plasma or serum. indicated for routine preg screening or work-up of autoimmune hemolysis
direct antiglobulin test (formerly the direct Coombs' test) will be (+) when either Ig or complement is actually bound to circulating RBCs of pt; ordered when immune hemolysis is suspected, for work-up of transfusion rxn, newborn infants with jaundice, work-up of anemia with unk cause
7 days after blood transfusion pts with no immunosuppression are likely to develop Abs to Rh thus pre-formed Abs wouldn't have been detected for initial transfusion, but if they are given blood with the same Rh subtype there will be an ANAMNESTIC RESPONSE where on 2nd exposure Ab production is ramped up quickly = delayed hemolytic transfusion rxn
Created by: sirprakes
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards