Aging by Weiner
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| Define senescence. | loss of function associated with passage of time
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| What anatomic changes are expected in the brain of an 80 y/o as part of the normal aging process? | 10% atrophy of brain tissue/white matter, cerebrum doesn't quite fill the cranium and gyri are diminished in size, sulci are larger
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| What percent loss of dopaminergic neurons is necessary before signs and sx of Parkinson dz are evident? | 80%
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| Name the pigment that accumulates in cells with again. | lipofuscin granules
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| What area of the brain is first vulnerable in Alzheimer's dz? | hippocampus
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| Name possible causes of brain senescence. | free radical damage, glycation, unfolding/misfolding of proteins, neurotoxic factors
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| What disorders are associated with hypercortisolemia? | major depression and PTSD, also hippocampal atrophy
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| What are autonomic effects of aging? | reduced beta-adrenergic sensitivity: lower max heart rate and contractility, etc. not as aware of hypoglycemia
decreased baroreceptor sensitivity: orthostatic HTN vasovagal syncope
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| Name histologic signs of Alzheimer dz. | neurofibrillary tangles, beta amyloid plaques
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| What are the 3 diseases associated with aging? | Parkinson, Alzheimer's and cerebrovascular dz
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