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Aging by Weiner

QuestionAnswer
Define senescence. loss of function associated with passage of time
What anatomic changes are expected in the brain of an 80 y/o as part of the normal aging process? 10% atrophy of brain tissue/white matter, cerebrum doesn't quite fill the cranium and gyri are diminished in size, sulci are larger
What percent loss of dopaminergic neurons is necessary before signs and sx of Parkinson dz are evident? 80%
Name the pigment that accumulates in cells with again. lipofuscin granules
What area of the brain is first vulnerable in Alzheimer's dz? hippocampus
Name possible causes of brain senescence. free radical damage, glycation, unfolding/misfolding of proteins, neurotoxic factors
What disorders are associated with hypercortisolemia? major depression and PTSD, also hippocampal atrophy
What are autonomic effects of aging? reduced beta-adrenergic sensitivity: lower max heart rate and contractility, etc. not as aware of hypoglycemia decreased baroreceptor sensitivity: orthostatic HTN vasovagal syncope
Name histologic signs of Alzheimer dz. neurofibrillary tangles, beta amyloid plaques
What are the 3 diseases associated with aging? Parkinson, Alzheimer's and cerebrovascular dz
Created by: sirprakes
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