1.13
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| Piperacillin/Tazobactam | Zosyn (IV)
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| Ticarcillin/Clavulanic Acid | Timentin (IV)
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| Cefazolin | Ancef (IV)
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| Cephalexin | Keflex (PO)
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| Cefaclor | Ceclor
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| Cefuroxime | Ceftin
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| Ceftriaxone | Rocephin; no neonates/ peds--> bilirubin buildup. Dont take with Calcium
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| Ceftazidime | Fortaz *pseudomonal
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| Cefepime | Maxipime *pseudomonal
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| Ceftaroline | Teflaro # anti-MRSA
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| Ertapenem | Invanz; longest half life, Q24, good for outpatient
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| Imipenem/Cilastatin | Primaxin
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| Meropenem | Merrem
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| Doripenem | Doribax
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| Aztreonam | Azactam
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| PO penicillins | 12,459
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| IV penicillins | 4 is IV and PO, everything else besides 12,459 up to 11
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| Type 1 | IgE; anaphylaxis
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| Type 2 | IgG, IgM
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| Type 3 | Antigen- Antibody
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| Type 4 | Not known T-lymphocytes
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| PCN drug interactions | tetracycline (antagonism), warfarin, aminoglycosides (same IV bag), and probenecid (prevents PCN elimination)
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| DON | NOT RENAL, positive only
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| B-lactamase inhibitors | clavulanic acid, sulbactam, tazobactam
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| Cefoxitin | Mefoxin, is a cephamycin
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| Cefotetan | Cefotan, is a cephamycin
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| Carbapenem "penems" ADR's and DI's | seizure and valproic acid; 5-10% cross allergic potential
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| What helps Imipenem from being broken down in renal tubule? | Cilastatin
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| Which Carbapenem isnt anti-pseudomonal? | Ertapenem
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| What do we give patients allergic to PNC? | Monobactam; Aztreonam (Azactam); gram negative and anti-pseudomonal
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| Polyenes | Ampho B (systemic) and Nystatin (not systemic)
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| Bind ergosterol--> pores that let in ions--> cell death | Polyenes (Ampho B and Nystatin)
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| Inhibits 14a- sterol demthylase--> no conversion lanosterol to ergosterol --> low ergosterol--> disrupted cell membrane | Azoles (Imidazoles and Triazoles)
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| Inhibit conversion of aqualene-->lanosterol--> squalene buildup (toxic) | allylamines/ benzylamines
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| Inhibits synthesis of B-1,3 glycan--> disrupts cell wall--> lysis --> death | Echinocandins (C.A.M-fungins)
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| Inhibits mitosis, may also inhibit RNA and DNA synthesis | Griseofulvin
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| Anti-fungal that inhibits DNA synthesis by messing with thymidylate synthase; converts to 5FU | Antimetabolites (Flucytosine)
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| Antifungal that inhibits transport of elements | Ciclopiroz (Tolnaftate)
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