Neuro Lecture 6: Sleep/Arousal
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What are some theories as to the function of sleep? | show 🗑
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What happens to circadian rhythms with the removal of cues (light)? | show 🗑
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show | retinohypothalamic tract
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show | Suprachiasmatic nucleus
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What is the photopigment contained in special ganglion cells in the retina? | show 🗑
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Is the suprachiasmatic nucleus responsible for sleep induction? Does it regulate the timing of sleep? | show 🗑
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show | pineal gland
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show | elevated
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Is aging associated with decreased or increased melatonin synthesis? | show 🗑
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show | decreased (both)
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Is sleep passive? | show 🗑
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Is sleep uniform? | show 🗑
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How many stages of non-REM sleep are there? | show 🗑
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show | EEG, EMG, and EOG (cortical, muscle, and eye electrical activity)
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What are the advantages and disadvantages of EEG? | show 🗑
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Is an EEG a correlate of deep neuronal activity? Or shallow? | show 🗑
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show | cortical pyramidal neurons + thalamocortical inputs to these neurons
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What is 1 word to describe the pattern of thalamocortical neurons during sleep? | show 🗑
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show | tonically active
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show | stimulation of rostral RAS (reticular activating system)
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show | coma
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What specifically causes sleep? | show 🗑
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show | cholinergic (ACh)
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show | GABAergic neurons
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During non-REM sleep, is neuronal activity high or low? | show 🗑
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During non-REM sleep, are metabolic rate and brain temperature high or low? | show 🗑
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During non-REM sleep, does sympathetic outflow increase or decrease? | show 🗑
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During non-REM sleep, does parasympathetic outflow increase or decrease? | show 🗑
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show | intact
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show | some skeletal muscle activity and slow eye-rolling movements
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show | beta (alert) and alpha (restful) *desynchronized
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show | alpha (10Hz)
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Which types of brain waves are present in stage 2 of non-REM sleep? Hz? | show 🗑
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Which types of brain waves are present in stage 3 of non-REM sleep? Hz? | show 🗑
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show | slow wave activity
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show | active
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show | Paradoxical sleep- brain temp & metabolic rate rise; body temp drifts toward ambient; muscle tone lost; somatic sensation diminished
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show | ~90 minutes through non-REM and REM stages
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show | transition between wakefulness to sleep- not repeated each cycle
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What happens to the REM stage with each cycle? | show 🗑
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show | pons-midbrain junction
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show | inhibition of the dorsal column nuclei and decreased sensation
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show | inhibited ventral LMN and muscle paralysis
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Which NT regulates dorsal column, sensation, ventral horn LMN, and muscle paralysis during REM sleep at the pons-midbrain junction? | show 🗑
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What happens to the cerebral cortex during REM sleep? | show 🗑
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show | paraventricular nucleus- corticotropin-releasing factor
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What is the mechanism by which cortisol is released from the adrenal glands? | show 🗑
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show | stress
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show | lateral hypothalamic area
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Stimulation of which hypothalamic nucleus induces sleep? | show 🗑
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show | suprachiasmatic nucleus
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show | tuberomamillary nucleus
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Which substance may act in preoptic nuclei and basal forebrain to promote sleep? | show 🗑
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show | in limbic-related areas (anterior cingulate cortex, amygdala, parahippocampal gyrus)
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Where is cortical inhibition primarily seen during REM sleep? | show 🗑
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Up to what % of the population are affected by chronic/extended sleep difficulty? | show 🗑
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Which conditions are more prevalent, too much sleep or not enough sleep? | show 🗑
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show | 15%
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show | 2%
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Do more people seek treatment for excessive sleepiness or chronic insomnia? | show 🗑
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show | persistent daytime sleepiness (biggest), cataplexy, sleep paralysis, hypnagogic hallucinations
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show | sudden loss of muscle tone with preserved consciousness
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What is sleep paralysis? | show 🗑
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show | vivid, dream-like hallucinations
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show | loss of hypothalamic neurons that contain orexin (hypocretin)
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What are 2 options for treatment of narcolepsy? | show 🗑
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show | brief arousals from sleep due to upper airway obstruction, daytime sleepiness- cardiovascular complications (arrhythmias, HTN)
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What is insomnia? What is one extreme example | show 🗑
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What is periodic limb movement disorder? | show 🗑
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What are parasomnias? | show 🗑
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show | decreases
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