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Neuro Lecture 6: Sleep/Arousal

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Question
Answer
What are some theories as to the function of sleep?   show
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What happens to circadian rhythms with the removal of cues (light)?   show
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show retinohypothalamic tract  
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show Suprachiasmatic nucleus  
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What is the photopigment contained in special ganglion cells in the retina?   show
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Is the suprachiasmatic nucleus responsible for sleep induction? Does it regulate the timing of sleep?   show
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show pineal gland  
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show elevated  
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Is aging associated with decreased or increased melatonin synthesis?   show
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show decreased (both)  
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Is sleep passive?   show
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Is sleep uniform?   show
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How many stages of non-REM sleep are there?   show
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show EEG, EMG, and EOG (cortical, muscle, and eye electrical activity)  
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What are the advantages and disadvantages of EEG?   show
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Is an EEG a correlate of deep neuronal activity? Or shallow?   show
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show cortical pyramidal neurons + thalamocortical inputs to these neurons  
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What is 1 word to describe the pattern of thalamocortical neurons during sleep?   show
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show tonically active  
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show stimulation of rostral RAS (reticular activating system)  
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show coma  
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What specifically causes sleep?   show
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show cholinergic (ACh)  
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show GABAergic neurons  
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During non-REM sleep, is neuronal activity high or low?   show
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During non-REM sleep, are metabolic rate and brain temperature high or low?   show
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During non-REM sleep, does sympathetic outflow increase or decrease?   show
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During non-REM sleep, does parasympathetic outflow increase or decrease?   show
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show intact  
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show some skeletal muscle activity and slow eye-rolling movements  
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show beta (alert) and alpha (restful) *desynchronized  
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show alpha (10Hz)  
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Which types of brain waves are present in stage 2 of non-REM sleep? Hz?   show
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Which types of brain waves are present in stage 3 of non-REM sleep? Hz?   show
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show slow wave activity  
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show active  
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show Paradoxical sleep- brain temp & metabolic rate rise; body temp drifts toward ambient; muscle tone lost; somatic sensation diminished  
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show ~90 minutes through non-REM and REM stages  
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show transition between wakefulness to sleep- not repeated each cycle  
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What happens to the REM stage with each cycle?   show
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show pons-midbrain junction  
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show inhibition of the dorsal column nuclei and decreased sensation  
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show inhibited ventral LMN and muscle paralysis  
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Which NT regulates dorsal column, sensation, ventral horn LMN, and muscle paralysis during REM sleep at the pons-midbrain junction?   show
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What happens to the cerebral cortex during REM sleep?   show
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show paraventricular nucleus- corticotropin-releasing factor  
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What is the mechanism by which cortisol is released from the adrenal glands?   show
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show stress  
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show lateral hypothalamic area  
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Stimulation of which hypothalamic nucleus induces sleep?   show
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show suprachiasmatic nucleus  
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show tuberomamillary nucleus  
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Which substance may act in preoptic nuclei and basal forebrain to promote sleep?   show
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show in limbic-related areas (anterior cingulate cortex, amygdala, parahippocampal gyrus)  
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Where is cortical inhibition primarily seen during REM sleep?   show
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Up to what % of the population are affected by chronic/extended sleep difficulty?   show
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Which conditions are more prevalent, too much sleep or not enough sleep?   show
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show 15%  
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show 2%  
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Do more people seek treatment for excessive sleepiness or chronic insomnia?   show
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show persistent daytime sleepiness (biggest), cataplexy, sleep paralysis, hypnagogic hallucinations  
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show sudden loss of muscle tone with preserved consciousness  
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What is sleep paralysis?   show
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show vivid, dream-like hallucinations  
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show loss of hypothalamic neurons that contain orexin (hypocretin)  
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What are 2 options for treatment of narcolepsy?   show
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show brief arousals from sleep due to upper airway obstruction, daytime sleepiness- cardiovascular complications (arrhythmias, HTN)  
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What is insomnia? What is one extreme example   show
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What is periodic limb movement disorder?   show
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What are parasomnias?   show
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show decreases  
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