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Lecture 6

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Acute overdose Dose Adults:   > 7.5-15 GM  
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Acute overdose Dose Children:   > 200 mg/kg  
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Acute overdose Dose Other factors (2)   Concomitant drugs/ chronic alcoholic Acetaminophen concentration  
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Chronic overdose   History  
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Chronic overdose Acetaminophen Concentration   (10mcg/mL)  
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Chronic overdose Hepatic transaminases    
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Chronic overdose Liver function tests   Pt INR Bilirubin  
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Chronic overdose Renal function   (order after liver tests) SCr BUN BMP  
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Chronic overdose Fulminant hepatic failure   Glucose Phosphate Lactate  
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Assessing Toxic Potential (7)   Dose Chronicity Serum APAP concentration Time since exposure Clinical manifestations Transaminases Presence of symptoms  
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Other labs Liver injury   Transaminases  
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Liver function   prothrombin time INR Bilirubin  
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