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APAP asses tox pot
Lecture 6
| Question | Answer |
|---|---|
| Acute overdose Dose Adults: | > 7.5-15 GM |
| Acute overdose Dose Children: | > 200 mg/kg |
| Acute overdose Dose Other factors (2) | Concomitant drugs/ chronic alcoholic Acetaminophen concentration |
| Chronic overdose | History |
| Chronic overdose Acetaminophen Concentration | (10mcg/mL) |
| Chronic overdose Hepatic transaminases | |
| Chronic overdose Liver function tests | Pt INR Bilirubin |
| Chronic overdose Renal function | (order after liver tests) SCr BUN BMP |
| Chronic overdose Fulminant hepatic failure | Glucose Phosphate Lactate |
| Assessing Toxic Potential (7) | Dose Chronicity Serum APAP concentration Time since exposure Clinical manifestations Transaminases Presence of symptoms |
| Other labs Liver injury | Transaminases |
| Liver function | prothrombin time INR Bilirubin |