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APAP asses tox pot

Lecture 6

QuestionAnswer
Acute overdose Dose Adults: > 7.5-15 GM
Acute overdose Dose Children: > 200 mg/kg
Acute overdose Dose Other factors (2) Concomitant drugs/ chronic alcoholic Acetaminophen concentration
Chronic overdose History
Chronic overdose Acetaminophen Concentration (10mcg/mL)
Chronic overdose Hepatic transaminases
Chronic overdose Liver function tests Pt INR Bilirubin
Chronic overdose Renal function (order after liver tests) SCr BUN BMP
Chronic overdose Fulminant hepatic failure Glucose Phosphate Lactate
Assessing Toxic Potential (7) Dose Chronicity Serum APAP concentration Time since exposure Clinical manifestations Transaminases Presence of symptoms
Other labs Liver injury Transaminases
Liver function prothrombin time INR Bilirubin
Created by: pberriochoa