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Tox lecture 6

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Phase
Time following ingestion
Characteristics
II   24 to 36 hours   Onset of liver injury with rise in AST/ALT  
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III   72 to 96 hours   Maximal hepatotoxicity. Peak liver function abnormalities (PT/bili), peak liver enzymes (AST/ALT) Possible fulminant hepatic failure (encephalopathy, acidosis). Death 3-5 days.  
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IV   4 days to 2 weeks   Resolution of hepatic dysfunction  
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I   0.5 to 24 hours   Anorexia, nausea, vomiting, malaise, pallor, diaphoresis. Rare metabolic acidosis, coma  
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