Clinical Aspect of Coagulation and Hemostasis II
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| Approximately what percentage of proximal DVTs are associated with pulmonary embolism? | show 🗑
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| What is the appearance of an extremitiy with an arterial thrombosis? | show 🗑
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| What type of clot is platelet rich and white in appearance? | show 🗑
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| show | True.
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| What are the antiphospholipid antibodies? | show 🗑
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| What are the clinical criteria for Antiphospholipid syndrome? | show 🗑
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| show | 1)Anti-cardiolipin Antibody (IgG or IgM) 2) Positive Lupus anticoagulant assay
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| What is the suggested evaluation for venous thromboembolism in a patient with no previous family or personal history? | show 🗑
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| What is the suggested evaluation for arterial thrombosis? | show 🗑
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| What are the accepted indications for thromboytic therapy? | show 🗑
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| show | 1)Major internal bleeding in the last 6 mo 2)Intracranial or intraspinal disease 3)Operation or biopsy in the preceding 10 days 4)HTN (sys >200, dia>110) 5)Active endocarditis 6)Pericarditis 7)Aneurysm 8)Presence of bleeding disorder
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| What is the mechanism of Argatroban? | show 🗑
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| What is the mechanism of Bivalirudin? | show 🗑
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| What is the mechanism of Lepirudin? | show 🗑
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| show | 1)Heparin 2)Low Molecular Weight Heparin 3)Fondaparinux
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| show | 1)aPTT reagents differ in phospholipid content and contact activators 2)aPTT and heparin levels may be discordant due to effects of plasma proteins
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| Factor Xa to Factor IIa activity of unfractionated heparin vs. low molecular weight heparin | show 🗑
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| What are the advantages of LMWH? | show 🗑
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| (T or F) LMWH never need monitoring. | show 🗑
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| (T or F) LMWH is fully reversible with protamine. | show 🗑
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| show | Varies by dose (average is 1-2 hours)
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| What is the half-life of LMWH? | show 🗑
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| show | 15-18 hours
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| show | Protamine
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| show | No
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| show | Renally
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| show | Renally
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| How are the anticoagulant effects monitored by LMWH? | show 🗑
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| show | Anti-Xa assay
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| How is heparin administered? | show 🗑
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| How is LMWH administered? | show 🗑
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| How is fondaparinux administered? | show 🗑
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| show | 39-51 mins
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| show | 1.5 hours
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| What is the half-life of Bivalirudin? | show 🗑
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| show | No
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| show | No
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| Are the anticoagulant effects of Bivalirudin reversible? | show 🗑
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| show | Metabolized by the liver
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| show | Renally
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| How is Bivalirudin excreted? | show 🗑
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| How is Argatroban administered? | show 🗑
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| show | IV
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| show | IV
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| What is the half-life of warfarin? | show 🗑
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| show | 1)Bleeding 2)Warfarin induced skin necrosis 3)Cholestatic jaundice 4)Nausea/vomiting 5)Alopecia 6)Mouth ulcers 7)Rash
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