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misc. questions
| Question | Answer |
|---|---|
| Three classes of hormones | steroids, proteins( peptides or goycoproteins), and amines |
| Steroid hormone synthesis is regulated through | negative feedback by another hormone (e.g., cortisol/ACTH) |
| Protein hormone synthesis is regulated through | change in analyte concentration in serum (e.g., insulin/glucose) and negative feedback by another hormone (e.g., testosterone/FSH) |
| Amine hormone synthesis is regulated by | nerve stimulation, antoher hormone(e.g., thyroxine/TSH), and negataive feedback |
| Examples of clinically significant steroid hormones | cortisol, aldosterone, testosterone, estrogen, progesterone |
| Examples of clinically significant protein hormones | FSH, LH, TSH, hCG, insulin, glucagon, parathyroid hormone, growth hormone, and prolactin |
| Examples of clinically significant amine hormones | epinephrine,norepinephrine, thyroxine and triiodothyronine |
| Commonly used methods for quantifying hormones include electrochemiluminescent immunoassay (Electro CLIA), high performance liquid chromatrography (HPLC) | enzyme-multiplied immunoassay technique (EMIT),fluorescent immunoassay (FIA),fluorescent polarization immunoassay (FPIA), and chemiluminescent immunoassay (CLIA) |
| Hormones produced by the hypothalamus | corticotropin-releasing hormone CRH, Gonadotropin-releasing hormone GnRH, Growth hormone-releasing hormone GHGRH, Thyrotropin-releasing hormone TRH, Dopamine,and Somatostain |
| a hormone that inhibits prolactin release | Dopamine |
| a hormone that inhibits secretion of TSH and GH | Somatostatin |
| a hormone produce by hypothalamus that stimulates secretion of adrenocoticotropic hormone (ACTH) | Corticotropin-releasing hormone (CRH) |
| a hormone produce by the hypothalamus that stimulates secretion of FSH and LH | Gonadotropin-releasing hormone (GnRH) |
| also known as vasopressin | antidiuretic hormone |
| ACTH and cortisol exhibit diurnal variation, with highest levels in what time? | highest level in the morning and lowest level in the late afternoon to early evening |
| Growth hormone is also known as | somatotropin hormone |
| criteria for diagnosis of DM, 1. symptoms of diabetes plus random plasma glucose of = or > 200 mg/dl (11.1mmol/L), 2. FPG of = or > 126 mg/dl (7.0 mmol/L) and | 3. 2 Hour post load glucose + or > 200 mg/dL (11.1 mm0l/L) during a n OGTT, using a glucose load of 75 g anydrous glucose dissolved in water. |
| is the reference method for glucose test | hexokinase method. Other tests include glucose oxidase method and glucose dehydrogenase method |
| The increase in absorbance of NADPH at 340 nm is measured as directly proportional to glucose in what method? | hexokinase method. this involves 2 coupled reactions |
| this method is specific for beta D-glucose | glucose oxidase method.( glucose+ O2---->gluconic acid + H2O2 ) with glucose oxidase as the enzyme catalyst. |
| Glucose + ATP----> G6PO4 + ADP with what enzyme as catalyst | hexokinase, with coenzyme Mg2+ |
| Proinsulin is cleaved into the active hormone, insulin, and an inactive peptide called | C-peptide. this peptide reflects the production of endogenous insulin |
| the presence of autoantibodies to pancreatic islet markers confirms a diagnosis of what type of diabetes | type 1 diabetes. Islet cell cytoplasmic autoantibodies are seen at the onset of 70% to 80% of type 1 diabetes cases. |
| Glutamic acid decarboxylase autoantibodies are also found at the onset of 70% to 80% of what type of diabetes cases, and insulinoma- 2–associated autoantibodies are found with about 60% of such cases | type 1 diabetes |
| In both diabetic and nondiabetic critically ill patients, hyperlycemia is associated with | impaired immunity that results in increaseed susceptibility to infection. |
| is associated with pathological changes in both diabetic and nondiabetic patients, such as impaired immunity, blindness, renal disease, and neuropathy | Hyperglycemia |
| is associated with cardiovasculardisorders, stroke, and limb amputation | Hyperglycemia of diabetes |
| Glycated hemoglobin normal value is | 4%-6%. also called glycosylated hemoglobin or HbA1c |
| are by-products of excessive beta-oxidation of fatty acids | KETONES.They are beta-hydroxybutyric acid(is present in large amount 78%), acetoacetate 20% and acetone 2% are products of this process. |
| is defined as blood pressure greater than or equal to 140/90 mm Hg | Hypertension |
| is a term that is used to describe albumin in urine in amounts that are slightly above normal | MICROALBUMINURIA, is sometimes described as "dipstick-negative albuminuria" since urine dipsticks are not sensitive to these small amounts. |
| Sodium nitroprusside test and B-Hydroxybutyrate Dehydrogenase method are test methodology for | Ketones |
| is a common occurence in the ketoacidosis of diabetes | Dehydration |