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| Question | Answer |
|---|---|
| Pathogen or saprophyte? -Leptospira interrogans; -Leptospira biflexa | L. interrogans: pathogen; L. biflexa: saprophyte |
| Leptospira: list 4 characteristics of host-adapted serovars | milder disease - mild, sporadic infections; long-term colonization of urogenital tract; venereal transmission; low-titer, long-lasting immune response (persistent) |
| Leptospira: list 3 characteristics of non-adapted serovars | severe infections; brief carrier state; high-titer immune response |
| Leptospira: what is the maintenance host/reservoir for the serovar icterohaemorrhagiae? | rodents |
| Leptospira: what is the maintenance host/reservoir for the serovar grippotyphosa? | rodents |
| Leptospira: what is the maintenance host/reservoir for the serovar canicola? | dogs |
| Leptospira: what is the maintenance host/reservoir for the serovar bratislava? | swine |
| Leptospira: what is the maintenance host/reservoir for the serovar pomona? | cattle, swine |
| Leptospira: what is the maintenance host/reservoir for the serovar hardjo? | cattle |
| leptospira can OR cannot penetrate intact skin? | cannot; must have broken skin |
| in canine leptospirosis, which serovars were used in "old" vs "new" vaccines? | old: icterohaemorrhagiae, canicola; new: grippotyphosa, pomona |
| which serovar causes acute bovine leptospirosis? | pomona; causes abortion storms |
| which serovar causes subacute bovine leptospirosis? | hardjo; causes abortion/stillborn/weak calves, but not in a storm |
| discuss leptospira zoonosis | all serovars are potential human pathogens; cause flu-like symptoms |
| Leptospira: which serovars infect horses? | pomona, others; abortion, and recurrent uveitis (more common) ensues |
| Leptospira: which serovars infect dogs | grippotyphosa, icterohaemorrhagiae, canicola, pomona; hepatic/renal disease ensues |
| Leptospira: which serovars infect cattle? | pomona, hardjo; abortion ensues |
| most common animal affected by Borrelia burgdorferi (lyme disease)? | dogs > horses > cattle > cats |
| what is special about vaccine for borrelia in dogs? | works in tick, not the dog; blocks transmission; immunity is short-lived; includes bacterin - both OspA & OspC, but most dogs don't respond to OspC - dogs only make Ab to OspA OR can be recombinant OspA only |
| Lyme disease symptoms | most are asymptomatic; transient fever, anorexia, arthritis (slowly progressive); rarely: renal disease, heart disease, neurologic signs |
| B. Burgdorferi zoonosis? | yes; animal-> human transmission; indirect through a tick vector but NOT dog -> human |
| Why is C6 antibody useful in diagnostics for B. burgdorferi? | only appear in exposed animals; no Ab's in response to vaccination; will be detected before clinical symptoms appear |
| which bacterium causes gas bubbles in infected tissue? | clostridium; also cause pitting edema |
| C. novyi type D used to be named what? | C. haemolyticum |
| why does Clostridium botulinum have no endotoxins? | it is not gram - |
| what species are most susceptible to C. tetani/ | man, horses > ruminants > pigs > dogs, cats |
| predisposing features for Fusobacterium necrophorum in cattle? | lead to liver abscesses; grain overload, lactic acidosis, rumenitis -> Fusobacterium invades rumen wall -> reaches liver via portal vein |
| what type of envirtonment does dichelobacter like? | warm, wet, muddy conditions |
| mycoplasma: are large-colony type or small-colony type more virulent | small-colony type ar emore virulent |
| characterize the bovine mastitis caused by mycoplasma bovis | can be acute or chronic; contagious! |
| how is mycoplasma spread in poultry? | aerosol (horizontal); hatching egg (vertical) |
| characteristics of icteroanemia/eperythrozoonosis? | Mycoplasma suis - porcine infection; acute hemolytic anemia, decreased conception, weak neonates, necrosis of extremities; transmitted by biting arthropods |
| Nomenclature change: what is the old name of Ehrlichia ruminantium? | cowdria ruminantium |
| Nomenclature change: what is the old name of anaplasma phagocytophilum? | ehrlichia phagocytophila, ehrlichia equi |
| Nomenclature change: what is the old name of anaplasma platys? | ehrlichia platys |
| Nomenclature change: what is the old name of neorickettsia risticii? | ehrlichia risticii |
| Nomenclature change: what is the old name of coxiella burnetii? | rickettsia burnetti |
| rocky mountain spotted fever clinical sympotoms | fever, vomiting, diarrhea, thrombosis, small hemorrhages (petechiae), lymph node enlargement, joint/muscle tenderness |
| ehrlichia canis, ewingii: acute vs subclinical vs chronic phases? | acute: fever, LN enlargement; subclinical: asymptomatic, elimination of bacterium; chronic: vasculitis, thrombocytopenia (immune-mediated?), hemorrhage |
| Ehrlichia zoonosis? | E. ewingii = human granulocytic ehrliciosis; E. canis = rare; E. chaffeensis = human monocytic ehrlichiosis, similar to E. canis |
| what animals/cells are attacked by anaplasma marginale? | cattle, erythrocytes |
| what animals/cells are attacked by anaplasma phagocytophilum? | ruminants, horses, dogs, human; granulocytes |
| what animals/cells are attacked by anaplasma platys? | dogs, platelets |
| 4 stages of anaplasma marginale? | incubation -> development -> convalescent -> carrier |
| neorickettsia: reservoir? intermediate host? | R: flukes (trematodes); IH: snails, fish (salmon) |
| Coxiella burnetti (Q fever) zoonosis | occupational disease: farmers, veterinarians, abbatoir workers; flu-like symptoms |
| C. burnetti - biosecurity? | has been weaponized; efficient aerosol transmission; survives in environment |
| Q fever in animals? | most infections are asymptomatic or latent; sporadic abortions |
| all chlamydophila used to be called what? | chlamydia psittaci |
| respiratory symptoms in M. gallisepticum & C. psittaci? | M: coughing, nasal discharge, air sacculitis; C: oculonasal discharge, respiratory distress, air sacculitis (also causes loss of condition systemically & diarrhea) |
| Chlamydophila psittaci: shedding? | may occur sporadically over long periods of time; stress may precipitate disease/shedding |
| Chlamydophila psittaci: zoonosis? | reportable; causes Psittacosis - flu-like, pneumonia; from pet birds & poultry; at risk - bird owners, pet shop employees, veterinarians, poultry workers |
| chlamydophilia felis: persistence | disease resolves without treatment, but organisms may persist; shedding of agent may be prolongs, stress may lead to clinical relapse |
| chlamydophilia felis: zoonosis? | mild conjunctivitis; rare |
| chlamydophilia abortus & abortions | sporadic or abortion storms, depending on flock immunity; organism may remain latent until late pregnancy |
| chlamydophilia abortus: zoonosis? | reports of clamydial abortion following exposure to aborting sheep; at risk: abattoir workers, vaccine manufacturing workers, laboratory scientists |
| fungi are more closely related to plants or animals? | animals |
| ways to classify fungi? mold/yeast/fungi-like | mold (multicell, filamentous/fuzzy)/yeast (single cell, reproduce by budding)/ fungal-like (resemble fungi) |
| way to classify fungy? disease | cutaneous/SubQ / systemic / opportunistic / fungal-like |
| microsporum canis | #1 dermatophyte at TVMDL; wide host range (mostly cat/dog); cat - primary reservoir, often asymptomatic; only animal dermatophyte that is wood's light + |
| microsporum gypseum | #2 dermatophyte at TVMDL; wide host range (dog, cat, horse); reservoir: soil |
| trichophyton mentagrophytes | #3 most common dermatophyte at TVMDL; wide host range (cat, dog, cattle); reservoir: rodent |
| sporothrix schenckii: transmission? | puncture wounds from thorns, bites, etc |
| sporotrichosis: zoonotic? | yes; direct contact with lesions/contaminated bandages; especially from cats; cats shed fungus in exudates, feces; can be isolated from clinically normal cats |
| characteristics of systemic fungi (5) | agents of 'deep mycoses'; thermally dimorphic; infection by inhalation; host factors important in disease course; generally noncontagious (most infections from the environment) |
| 3 varieties of H. capsulatum? Which is in the US? | H. capsulatum farciminosum (N Africa, Europe, India, Russia); H. capsulatum duboisii (Africa); H. capsulatum capsulatum (US) |
| H. capsulatum capsulatum - reservoir & transmission? | world-wide; mississippi & ohio river valleys; strongly associated with bird & bat droppings; transmitted by inhalation |
| Histoplasmosis: canine infection | most susceptible species; young outdoor sporting breeds; 3 forms - subclinical (most common), pulmonary, disseminate (GI, skin, lymphatics, CNS, BM, eyes, liver, spleen) |
| Histoplasmosis: feline infection | rare, progressive, debilitating (weight loss, lethargy, fever); 44% of cats in endemic areas may harbor yeast in tissues |
| Histoplasmosis: public health | most common human pulmonary mycosis; disseminated disease (impairment of host immunity, elderly/immunocompromised, dormancy in macrophages & reactivation); disease in healthy indiv: overwhelming inoculum of organisms; interspp. transmission unlikely |
| Blastomycosis: canine infection | dog/human - natural host; 25% infections are fatal; clinical forms-systemic/disseminated or cutaneous; clinical signs depend on organ affected (dyspnea, anorexia, depression, lameness, lymphadenopathy, skin lesions) |
| Blastomycosis: public health | zoonotic transmission uncommon - percutaneous infection (bite from a dog), vets performing necropsies; humans - natural host; low prevalence in endemic areas; pneumonia & weight loss most common symptoms |
| Coccidioidomycosis: importance? | most virulent fungal pathogen; fewer than 10 arthroconidia can cause infection; CDC/APHIS select agent status |
| coccidioidomycosis: 2 species | Coccidioides immitis (San Joaquin Valley, CA); coccidioides posadasii |
| coccidioidomycosis: who does it infect? | most commonly: humans, dogs, horses, llamas; other: cattle, sheep, swine, cats, exotic spp |
| coccidioidomycosis: canine infection | 80% pulmonary dz, 20% disseminated dz; weight loss, dyspnea, anorexia, cough, lameness, draining tracts, abscesses |
| coccidioidomycosis: equine infection | disseminated most common |
| coccidioidomycosis: llama infection | VERY susceptible; respiratory, dermatitis, osteomyelitis, meningitis |
| coccidioidomycosis: public health | >50% infections in humans are asymptomatic; influenza-like to severe pneumonia; disseminated disease (bones, joints, skin, CNS), fatal in immunocomp indiv; zoonotic trans - spherules (tissue form) are not infectious, possible transmission in necropsy |
| cryptococcosis: 2 pathogenic species | cryptococcus neoformans, cryptococcus gattii |
| 4 antigenic types of cryptococcosis neoformans | A: C. neoformans grubii; B&C: C. neoformans gattii; D: C. neoformans neoformans |
| cryptococcosis: feline infection | most common systemic fungal infection in cats; primary site - nasal cavity (rostral cavity - mycotic rhinitis, nasal d/c, distortion of nasal cavity; caudal cavity - olfactory bulbs->meningitis); hematogenous spread-cutaneous, ocular lesions |
| cryptococcosis: canine infection | less common than in cats; respiratory tract, eye, skin, periphral LN, CNS |
| cryptococcosis: equine infection | meningitis, nasal granuloma, abortion, pneumonia |
| cryptococcosis: avian infection | rarely affected clinically; are reservoirs; sporadic infection in exotic & wild birds |
| C. gattii infects whom? | normal, healthy humans & animals; cats, dogs, goats, sheep, horses, koalas, opposums, cheetah |
| which systemic fungi are or are NOT thermally dimorphic? | all are! Coccidioidomycosis, blastomycosis, histoplasmosis, cryptococcosis |