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UQVet3Pharm
Question | Answer |
---|---|
Phenylephrine | alpha agonist urinary incontinence, mydriatic |
Xylazine | alpha2 agonist tranquilzer |
Ephidrine/pseudoephidrine | alpha and beta agonist nasal decongestant and urinary incontinence |
Dobutamine | beta1 agonist inotrope and increases BP in anaesth |
Isoprenaline | beta1 and beta2 agonist inotrope (SE: myocard necrosis) and bronchodilator |
Salbutamol | beta2 agonist bronchodilator |
Desipramine, cocaine | Indirect acting adrenergic agonist Block transporters so no NT reuptake |
MAO and COMT inhibitors - indirect acting agonists | Inhibit enzymes that degrade catecholamines and adrenomimetics |
Prazosin | alpha1 antagonist Tx: hypertension and CHF |
Phenoxybenzamine | alpha1 and 2 antagonist Tx: hypertension |
Phentolamine | alpha1 and 2 antagonist Tx: hypertension |
Yohimbine | alpha2 antagonist Tx: antidote for alpha2 agonist tranquilizers |
Labetalol | beta1 (and some alpha) antagonism Decrease BP |
Atenolol | beta1 Decrease HR and BP |
Propanolol | beta1 and 2 Tx: hypertension, dysrhytmias, hypertrophic cardiomyopathy and anxiety. Caution in airway dz dt beta2 antagonism |
Pilocarpine | Muscarinic receptor agonist Pupillary constriction Better half life than Ach |
Bethanecol | Muscarinic receptor (w little heart and vasc sm m effects) Micturition and GI peristalsis Not degraded by cholinesterases |
Indirect acting cholinergic agonists MOA | Inhibit cholinesterases --> cholinomimetic effect. Reversible or irreversible binding |
Physostigmine | Indirect acting cholinomimetic - reversible Gets into BBB Miosis and Tx atropine poisoning |
Neostigmine | Indirect acting cholinomimetic - reversible Doesn't get into brain Tx: myasthenia gravis |
Ecothiaphate | Indirect acting cholinomimetic OP - thus irreversible binding Tx: glaucoma |
Cisapride | Indirect acting cholinomimetic MOA = incr ACh release Increases gut motility |
OP poisoning Tx? | Atropine blocks ACh action at muscarinic receptors |
Atropine | Parasympatholytic Tx: inflam eye conditions |
Scopolamine | Parasympatholytic For bowel - antiemetic and stops gut spasms (Buscopan) |
Glycopyrrolate | Parasympatholytic Pre-anaesthetic (Decr salivation so less likely to inhale) |
Propantheline | Parasympatholytic For bladder/GIT spasms |