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Equine Endocrine Dz

PPID, EMS

QuestionAnswer
Most common endocrine disorder of horses, ponies, and equids Pituitary Pars Intermedia Dysfunction
PPID Pathogenesis neurodegeneration of hypothalamus --> decreased dopamine --> overproduction of pituitary hormones (POMC, ACTH --> cortisol)
PPID Signalment Morgans & Ponies 7-42 years
Hirsutism long curly hair (pathonuemonic for PPID)
Why should you NOT test for elevated PI hormones in August-October? Naturally elevated this time of year; Re-test in January
Gold Standard Test for PPID Dexamethasone Suppression Test - positive if cortisol >1 ug/dl
Most effective PPID medication that targets the hypothalamus-pituitary axis Pergolide mesylate - dopamine agonist
Serotonin antagonist often used in conjunction with Pergolide to manage PPID Cyproheptadine
PPID medication that acts on adrenal gland to decrease cortisol production Trilostane
Definition of Equine Metabolic Syndrome 1) Insulin Resistance 2) Laminitis 3) Obesity/Regional adiposity
EMS Signalment Ponies, Morgans, Fjords, Arabians, Peruvian Pasos, Paso Finos >5 years
Name two tests that can be used to diagnose EMS Resting serum insulin; Combined glucose-insulin test
Positive Result for Combined Glucose-Insulin Test (EMS) [blood glucose] > baseline for more than 35min; [serum insulin] >100 uU/ml at 45min
Short-term thyroid supplement that can be used to improve insulin sensitivity and accelerate weight loss in EMS horse Levothyroxine Therapy (Thyro L)
Created by: 26509889