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Pharmacology Drugs 9
Protozals-Corticosteroids
| Question | Answer |
|---|---|
| what are some treatment options for dogs and cats with cryptosporidiosis? | tylosin (10-15mg/kg TID for 14d-- dogs); Azithromycin (5-10mg/kg BID for 5-7d-- dogs & 7-12mg/kg BID for 5-7d-- cats); Nitazoxanide |
| what is the dosage of nitazoxanide in dogs 24-47mo old? | 100mg BID for 5 days |
| what is the dosage of nitazoxanide in dogs 4-11yr old? | 200mg BID for 5 days |
| what is the dosage of nitazoxanide in dogs that the CVT recommends? | 100mg/kg po for 3days |
| why wouldn't you administer paramomycin orally for the treatment of cryptosporidiosis? | poorly absorbed aminoglycoside antibiotic |
| how does paramomycin work? | binds the small subunit ribosomal RNA and inhibits protein synthesis |
| What at the direct and indirect effects of paramomycin? | direct= on protozoans; indirect= on nutrient withdrawl caused by the inhibition of bacterial protein synthesis and destruction of bacterial flora |
| why wouldn't you choose to use paramomycin in dogs? | while clinical signs cleared, relapses of the animal back to having cryptosporidiosis occur 2 mos after ending treatment initially |
| while paramomycin works pretty well in cats, why wouldn't you use it? | can cause kidney failure |
| what are the trade names of nitozoxanide for humans and horses and what does nitozoxanide treat in it? | humasn= alinia, treats cryptosporidia and giardia; horses= navigator, treats EPM and sarcocystis neurona |
| nitozoxanide seems to exhibit a broad spectrum of activities against a wide variety of parasites including? | Intestinal and tissue-dwelling helminths; Protozoa – at least Giardia and Crypto; Enteric bacteria infecting animals and humans |
| what does nitozoxanide interfere with? | pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism. Basically "shuts down bacterial respiration." |
| Tritrichomonas foetus is particularly bad for which group of cats/ | cattery cats and show cats |
| is there a cyst phase for tritrichomonas foetus? | no |
| what do you use to treat tritrichomonas foetus? | ronidazole |
| what are two treatments for giardia and what should you never use? | metronidazle and fenbendazole; albendazole |
| if one animal in a multi-animal household has giardia, should you treat only the infected animal? why/why not? | no, treat them all b/c the other animals can be asymptomatic carriers. |
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