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VetMed Pharm12
Haemostasis Pharmacology
Question | Answer |
---|---|
Heparin MOA | binds to plasma anti-thrombin III --> forms AT-III-heparin-thrombin complex inhibits biochemical activity of thrombin suppresses thrombin-mediated fibrinogen suppresses other coagulation factors suppresses normal platelet function |
Danaparoid MOA | anti-thrombin III inhibition of factor Xa tx deep-vein thrombosis |
Streptokinase MOA | promotes generation of active plasmin |
Anti-platelet Therapy | facilitates endothelial repair at sites of vascular injury |
Arterial vs. Venous Thrombosis | arterial - >platelets venous - >fibrin |
Multiple Clinical Conditions RxTx by Heparin | DIC vascular thrombosis septic pleuritis and peritonitis hypercoag states - nephritic syndrome, cushing's, cardiomyopathy angina & myocardial infarction, cardiac bypass (humans) lipemia conditions r |
Molecular Disadvantages of Excessively High Doses of Aspirin in Tx DIC/Arterial Thrombosis | inhibits biochem activity of platelet thromboxane synthesis and vascular endothelial PGI2 --> exacerbates hypercoag disorders |
Heparin Therapy Sequelae | increased hemorrhagic tendencies premature/accelerated removal of RBCs (EV hemolysis) |
NSAIDs Therapy Sequelae | inhibits biochem activity of platelet thromboxane synthesis and vascular endothelial PGI2 --> exacerbates hypercoag disorders |
Coag Factors Inhibited by Heparin | IIa IXa Xa Xia thrombin anti-thrombin III |
Antidote for Heparin Therapy | protamine sulfate |
RxTx to Dx Certain Coag Factor Deficiencies | aspirin |
Precautions to Admin of Whole Blood, Plasma, Platelet-Enriched Plasma | tx primary dz state cross-match donor and recipient simultaneous tx with anti-coag and/or anti-platelet therapy |