Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

VetMed Pharm10

Anti-Neoplastic Agents

Phase-Specific/Selective Chemotherapeutic Agents dependent on the percent of a cancer cell population that exists within a specific stage or phase of the cell cycle
Phase Non-Specific/Non-Selective Chemotherapeutic Agents work independently of the percent of a cancer cell population that exists within a specific stage or phase of the cell cycle
Phase of the Cancer Cell Cycle Most Vulnerable to Most Chemo Agents mitosis (fast-growing)
Alkylating Agents MOA directly interact with nuclear DNA
Relative Growth Rates in Small Tumors vs. Larger/Mature Tumors larger, more mature tumors have slower or decreased cell division
What are Tumor "Stem-Cell" Populations? dividing cell populations
Classes of Anti-Neoplastic Agents (5) chemotherapeutics - rapidly dividing anti-hormone agents - palliative radiation therapy nuclear therapy immune modulating agents - enhance immune system
Multi-Modal Therapeutic Strategies regiments for the management of cancer that commonly employ drugs + adjunct therapy (biotherapeutics, hyperthermia, immune-modulating agents, radiotherapy, cryotherapy, surgery)
Alkylating Agents MOA form covalent bond with nucleotides within nucleic acid strands
Anti-metabolites MOA inhibit biochemical activity of key enzymes involved in synthesis of nucleic acid strands
Immune Modulating Agents MOA IL-2: enhances cytotoxic activity of tumor-infiltrating T-lymphocytes Cimetidine: enhances cell-mediated immunity Lavamisol: tx's leukemias/granulomatous dz, enhances recovery
Hormonal/Anti-hormonals MOA inhibits steroid hormone synthesis
Immunoglobulins MOA selectively target tumor-specific antigens or receptor complexes
NSAIDs MOA inhibit PGE production, tumor-derived COX-2
Tumor-Derived COX-2 Actions block dendritic cell function block CD4+ and CD8+ T-cell proliferation and function
Mechanisms of Chemotherapeutic Resistance pharmacokinetic-based resistance cellular kinetic resistance genetic and biochemical resistance multi-drug resistance
Define Cure total elimination of a neoplastic disease state
Define Remission clinical signs of disease can not be appreciated but microscopic evidence of cancer still exists
Define Palliative Cancer Therapy treatment to reduce severity of clinical signs and patient discomfort
Created by: 26509889



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards