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VetMed Pharm10

Anti-Neoplastic Agents

Phase-Specific/Selective Chemotherapeutic Agents dependent on the percent of a cancer cell population that exists within a specific stage or phase of the cell cycle
Phase Non-Specific/Non-Selective Chemotherapeutic Agents work independently of the percent of a cancer cell population that exists within a specific stage or phase of the cell cycle
Phase of the Cancer Cell Cycle Most Vulnerable to Most Chemo Agents mitosis (fast-growing)
Alkylating Agents MOA directly interact with nuclear DNA
Relative Growth Rates in Small Tumors vs. Larger/Mature Tumors larger, more mature tumors have slower or decreased cell division
What are Tumor "Stem-Cell" Populations? dividing cell populations
Classes of Anti-Neoplastic Agents (5) chemotherapeutics - rapidly dividing anti-hormone agents - palliative radiation therapy nuclear therapy immune modulating agents - enhance immune system
Multi-Modal Therapeutic Strategies regiments for the management of cancer that commonly employ drugs + adjunct therapy (biotherapeutics, hyperthermia, immune-modulating agents, radiotherapy, cryotherapy, surgery)
Alkylating Agents MOA form covalent bond with nucleotides within nucleic acid strands
Anti-metabolites MOA inhibit biochemical activity of key enzymes involved in synthesis of nucleic acid strands
Immune Modulating Agents MOA IL-2: enhances cytotoxic activity of tumor-infiltrating T-lymphocytes Cimetidine: enhances cell-mediated immunity Lavamisol: tx's leukemias/granulomatous dz, enhances recovery
Hormonal/Anti-hormonals MOA inhibits steroid hormone synthesis
Immunoglobulins MOA selectively target tumor-specific antigens or receptor complexes
NSAIDs MOA inhibit PGE production, tumor-derived COX-2
Tumor-Derived COX-2 Actions block dendritic cell function block CD4+ and CD8+ T-cell proliferation and function
Mechanisms of Chemotherapeutic Resistance pharmacokinetic-based resistance cellular kinetic resistance genetic and biochemical resistance multi-drug resistance
Define Cure total elimination of a neoplastic disease state
Define Remission clinical signs of disease can not be appreciated but microscopic evidence of cancer still exists
Define Palliative Cancer Therapy treatment to reduce severity of clinical signs and patient discomfort
Created by: 26509889