click below
click below
Normal Size Small Size show me how
VetMed Pharmacology7
VetMet Pharmacology - Fluid Therapy & Electrolytes
| Question | Answer |
|---|---|
| Percentage of BW as Intracellular Fluid | 30-40% |
| Percentage of BW as Extracellular Fluid | 20% |
| Percentage of BW as Plasma Volume | 4-6% |
| Percentage of BW as Interstitial Fluid | 10-12% |
| Percentage of BW as Transcellular Fluid | 6-10% |
| Percentage of Adult BW as Total Body Water | 60% |
| Percentage of Neonate BW as Total Body Water | 80% |
| Primary Extracellular Cation | Na+ |
| Primary Intracellular Cation | K+ |
| Primary Extracellular Anion | Cl- |
| Primary Intracellular Anion | PO4- proteins |
| General Guidelines for Administering Fluid Therapy | 50% of fluid deficit in first 3 hours re-evaluate hydration status every hour remaining 50% of fluid deficit over next 21 hour period |
| Dispersion of Physiological Saline | 2/3 --> interstitial fluid space 1/3 --> intravascular space |
| Dispersion of 5% Dextrose | 2/3 --> intracellular fluid space 1/3 --> extracellular fluid space (only 25% of which is IV) |
| Indications for Physiological Saline | acute plasma volume expansion correction of hyponatremia metabolic alkalosis diarrhea due to hyponatremia |
| Indications for 5% Dextrose | hypernatremia free H2O depletion carbohydrate source for NPO cases |
| Indications for 2.5% Dextrose and 0.45% Saline | avoids iatrogenic hypernatremia in blocked tom cats maintenance fluid (post-op equine colics) |
| Indications for Colloids/Hypertonic Saline/Hetastarch | hypoproteinemia caused by haemorrhage, liver disease, thermal burns |
| Maximum IV Administration for K+ | 0.5 mEq/kg/day |
| Causes of Hypokalemia | decreased dietary intake K+ wasting in kidney (severe dehydration) diuretic therapy |
| Causes of Hyperkalemia | decreased renal excretion (renal failure) iatrogenic causes early metabolic acidosis |
| Treatment of Hyperkalemia | Ca2+ gluconate insulin/dextrose bicarbonate (all drive K+ into cytosol of cells) |
| Treatment of Metabolic Acidosis | IV fluids (increase vascular O2 delivery) Na+HCO3- (normal lungs only) |
| Treatment of Metabolic Alkalosis | physiological saline Cl- and K+ to conserve H+ of paradoxical aciduria |
| Treatment of Respiratory Acidosis | improve pulmonary ventilation HPO3- (combines with H+ so can be renally excreted) |
| Treatment of Respiratory Alkalosis | reduce pulmonary ventilation rate/rebreathe physiological saline |