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VetMed Pharmacology6

VetMed Pharmacology - Adverse Rxns

Idiosyncratic Reactions an unexpected response to a pharmaceutical or pharmaceutical combination that is not frequently recognized for a given population of the same species, age and sex
Comparative Neonate Pharmacology have biochemically immature hepatic metabolizing schemes have immature mechanisms for renal and hepatic excretion have a larger extracellular fluid volume have an immature blood brain barrier
Type I Immune Hypersensitivity Reaction a pharmaceutical binds to proteins to form haptens which are recognized by the body as a foreign antigen excessive IgE is produced
"Shock Organs" Affected During Type I Reactions lung intestine liver
Type I Reaction Adjunct Therapy corticosteroids NSAIDs anti-histamines IV fluids local epinephrine injection
Type II Immune Hypersensitivity Reaction pharmaceutical binds to the surface membrane of a cell creating a "foreign antigen" and inducing an auto-immune response excessive IgG or IgM produced
Type III Immune Hypersensitivity Reaction hapten-pharmaceutical IgG complexes form and settle out in micro-capillary networks leading to local cytolysis and leukocyte infiltration
Type IV Immune Hypersensitivity Reaction antigen binding to multi-nucleated Langerhans cells, promoting a lymphokine release and macrophage infiltration excessive T-lymphocyte production
Created by: 26509889



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