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VetMed Pharmacology6
VetMed Pharmacology - Adverse Rxns
Question | Answer |
---|---|
Idiosyncratic Reactions | an unexpected response to a pharmaceutical or pharmaceutical combination that is not frequently recognized for a given population of the same species, age and sex |
Comparative Neonate Pharmacology | have biochemically immature hepatic metabolizing schemes have immature mechanisms for renal and hepatic excretion have a larger extracellular fluid volume have an immature blood brain barrier |
Type I Immune Hypersensitivity Reaction | a pharmaceutical binds to proteins to form haptens which are recognized by the body as a foreign antigen excessive IgE is produced |
"Shock Organs" Affected During Type I Reactions | lung intestine liver |
Type I Reaction Adjunct Therapy | corticosteroids NSAIDs anti-histamines IV fluids local epinephrine injection |
Type II Immune Hypersensitivity Reaction | pharmaceutical binds to the surface membrane of a cell creating a "foreign antigen" and inducing an auto-immune response excessive IgG or IgM produced |
Type III Immune Hypersensitivity Reaction | hapten-pharmaceutical IgG complexes form and settle out in micro-capillary networks leading to local cytolysis and leukocyte infiltration |
Type IV Immune Hypersensitivity Reaction | antigen binding to multi-nucleated Langerhans cells, promoting a lymphokine release and macrophage infiltration excessive T-lymphocyte production |