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VetMed Pharmacology5

VetMed Pharmacology - Excretion

Primary Routes of Excretion/Elimination renal/urinary (primary) hepatobiliary (secondary) pulmonary/respiratory gastrointestinal (bile or feces)
Secondary Routes of Excretion/Elimination saliva tears sweat hair exfoliation milk
MIC minimum inhibitor concentration of a specific anti-microbial/antibiotic agent necessary to kill or suppress growth of a given bacterial pathogen
Hepatic First-Pass Phenomenon extent a compound is removed from the blood/plasma after first transit cycle through the liver (e.g. Lidocaine)
Enterohepatic Recycling Phenomenon a pharm compound is minimally metabolized before being excreted in the bile and then re-absorbed through the intestines and the liver (e.g. Rifampin)
Mechanisms of Renal Excretion glomerular filtration & passive excretion active secretion facilitated non-selective mechanisms
Passive Renal Tubular Re-absorption ionized pharm enters the urinary plasma filtrate and is converted to its non-ionized form, allowing it to diffuse back across the renal lumen and re-enter the central intravascular compartment pKa values between 5 and 8
Pharmacokinetics a mathematical description of changes (declines) in the plasma concentrations of a pharm over a specific unit of time following initial administration
Created by: 26509889



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