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VetMed Pharmacology5
VetMed Pharmacology - Excretion
| Question | Answer |
|---|---|
| Primary Routes of Excretion/Elimination | renal/urinary (primary) hepatobiliary (secondary) pulmonary/respiratory gastrointestinal (bile or feces) |
| Secondary Routes of Excretion/Elimination | saliva tears sweat hair exfoliation milk |
| MIC | minimum inhibitor concentration of a specific anti-microbial/antibiotic agent necessary to kill or suppress growth of a given bacterial pathogen |
| Hepatic First-Pass Phenomenon | extent a compound is removed from the blood/plasma after first transit cycle through the liver (e.g. Lidocaine) |
| Enterohepatic Recycling Phenomenon | a pharm compound is minimally metabolized before being excreted in the bile and then re-absorbed through the intestines and the liver (e.g. Rifampin) |
| Mechanisms of Renal Excretion | glomerular filtration & passive excretion active secretion facilitated non-selective mechanisms |
| Passive Renal Tubular Re-absorption | ionized pharm enters the urinary plasma filtrate and is converted to its non-ionized form, allowing it to diffuse back across the renal lumen and re-enter the central intravascular compartment pKa values between 5 and 8 |
| Pharmacokinetics | a mathematical description of changes (declines) in the plasma concentrations of a pharm over a specific unit of time following initial administration |
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