Save
Busy. Please wait.
Log in using Clever
or

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

RBC Clin Med I

RBC Differential/Morphology

QuestionAnswer
RBC Maturation Stages 1. Stem Cell (nucleated) 2. Rubriblast (nucleated) 3. Prorubricyte (nucleated) 4. Rubricyte (basophilic & polychromatic) 5. Metarubricyte (nucleated) 6. Reticulocyte (anucleated) 7. Mature RBC (anucleated)
Reticulocytes Large, young RBCs which appear bluish when stained with Diff-Quik When stained with New Methylene Blue (NMB) they have dots, strings or clumps of basophilic material (DNA/RNA)
Mature RBCs Normal, mature RBCs: biconcave disks. Central pallor. Dog RBCs are ~ 7um and live ~ 100 days Cat RBCs ~5-6 um and live ~60 days Dogs exhibit an area in the middle of the cell which is more pale than surrounding cell. Cats much less pallor.
What am I looking for with a differential, in regards to RBCs? Morphology RBC: formation shape size color (chromia) inclusions (abnormal like fiber, bacteria, viruses
Agglutination Precipitation of RBCs out of blood Occurs as WBCs attack RBCs as if foreign Can suggest an autoimmune disease
Rouleax Formation RBCs stacked like coins RBC arrangement due to blood smear technique
Poikilocytosis Abnormally shaped RBCs Can be abnormally small, contain protusions or appear as a fragment
Types of Poikilocytes Acanthocytes (spur cells) Echinocytes (burr cells) Schistocytes Spherocytes Keratocytes Codocytes/Leptocytes (target cells) Stomatocytes Anulocytes Dacrocytes
Acanthocytes (spur cells) RBCs with cell membrane abnormalities Sort, irregular, unevenly spaced protusions Seen with hemangiosarcoma, a blood vessel tumor Blood moved thru intravascular tumor at high speed
Echinocytes (burr cells) Sharp, evenly spaced projections Can be drying artifact (crenation) Seen with renal disease and lymphosarcom... polydipsia/polyuria, dehydration, kidney pain
Schistocytes RBC fragments due to internal trauma, RBCs pushed thru fibrin strands Associated w hemangiosarcoma, (blood vessel that bleeds and clots repeatedly) Disseminated intravascular coagulopathy(DIC)... pet beins to spontaneously clot blood in ve
Spherocytes Smaller RBCs w no central pallor Appear as small, dense RBCs Associated with AIHA, autoimmune hemolytic anemia, where WBCs attack own RBCs RBCs decrease in size as WBCs attack
Keratocytes (helmet, blister or bite cells) Associated w hemangiosarcoma, neoplasia, glomerulonephritis, intravasular trauma and various hepatic diseases May contain pseudovacuole due to fibrin strands causing bisection and reconnection
Codocytes/Leptocytes Take a variety of shapes with different names: Target cells Folded cells aka Stomatocytes Barr cells aka knizocytes - rare
Anulocytes Bowl-shaped RBCs Due to loss of membrane flexibility that does not allow RBC to return to normal shape after passing thru capillary May be seen in any acute disease
Dacrocytes Tear-drop shaped Can be an artifact or seen in myeloproliferative diseases (spinal cord or bone marrow) If artifact, "tails" point in same direction
Poikilocytes Anisocytosis Anisochromia
Anisocytosis Abnormal variation in size of RBCs Macrocytosis=abnormally large RBCs, macrocytes Microcytosis=abnormally small RBCs, microcytes Normocytosis=normal sized RBCs
Anisochromia Hypochromia-hemoglobin deficiency; insufficient color Hyperchromia-hemoglobin excess; overabundance of color Normochromia-normal hemoglobin; normal color Polychromatophilia-RBCs w many colors If many reticulocytes do reticulocyte smear
RBC Inclusions Small bodies that are "included" in RBCs Presence indicates toxicity, RBC parasite, viral infection or disease
RBC Inclusions we will cover: Heinz bodies - feline and canine Hollow Jolly Bodies Basophillic Stippling Distemper Viral Inclusions Mycoplasma Haemofelis/canis Ehrlichia Babesia from brown dog tick
Heinz Bodies Small round projection from RBC surface Usually represents oxidation and denaturation of Hgb Seen in cats w DM, lymphoma and hyperthyrodism Looks blue when using NMB, clear w Diff-Quik Seen in dogs after eating onions, toxic drugs, acetamin
Howell Jolly Bodies Small fragments on nonfunctional nucleus that were not extruded as cell left marrow. Normally removed from blood by pitting action of spleen Appear as on dark staining body per cell Seen w regenerative anemia, pts on corticosteroids, splenect
Basophillic Stippling Round, dark blue granules in RBCs Granules are precipitated ribosomes and mitochondria Seen w toxic injury to bone marrow (lead poisoning), severe anemia, drug toxicity, severe burns or septicemia
Distemper Viral Inclusions Large aggregates of viral particles can form in cytoplasm of RBCs, WBCs and epithelial cells in many tissues during acute phase of infection
Mycoplasma Haemoncanis Rare in dogs Usually seen in splenectomy or immuno-suppressed pts Commonly appear as chain of small cocci or rods that stretch across the RBC surface Chains may branch
Mycoplasma Haemonfelis Fairly common bacterial parasite of cat RBCs AKA hemobartonellosis or feline infectious anemia Appear as small round, rod or ring-shaped structures that stain dark purple Most commonly appear as short rods on RBC periphery
Ehrlichia Type of rickettsial organism w many species Tick borne disease that affect WBCs and platelets Transmitted by brown dog tick Appears as small clusters called morulae in the cytoplasm Can result in neutropenia, thromocytopenia and anemia
Created by: mfjasp
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards