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Repro 11-12
Neuroendocrine behaviour and puberty
| Question | Answer |
|---|---|
| Endocrine glands in cattle | hypothalamus pituitary gonads (ovaries, testes) |
| Endocrine signalling | endocrine autocrine paracrine neurohormone |
| Hypothalamus | region at base of the brain neuroendocrine gland mediates hormonal and environmental influences on reproduction |
| Neuroendocrine gland | in the hypothalamus hormones released from terminals of axons into blood vessels that feed into anterior pituitary secretes GnRH |
| GnRH secretion | pulsatile release crucial pulse frequency determines pattern of FSH and LH secretion two systems regulate female gonadotropins |
| Systems regulating female gonadotropins | tonic/episodic system surge system (produces LH surge before ovulation) |
| Pituitary gland | consists of anterior pituitary and posterior pituitary |
| Anterior pituitary | releases FSH, LH, prolactin controlled by hypothalamic neurohormones via portal system |
| Posterior pituitary | stores and releases oxytocin |
| FSH | follicle stimulating hormone |
| LH | luteinising hormone |
| Female gonads (ovaries) | theca cells are stimulated by LH to produce androgens and progesterone Granulosa cells stimulated by FSH to produce oestrogen |
| Male gonads (testes) | leydig cells stimulated by LH to produce testosterone Sertoli cells stimulated by FSH to support spermatogenesis |
| Oestrogen function | behaviour follicle development positive feedback at high levels |
| Progesterone function | pregnancy maintenance negative feedback |
| Testosterone function | libido spermatogenesis secondary sex characteristics |
| Prostaglandin | produced by uterus causes luteolysis triggers CL regression |
| Negative feedback (hormone feedback loops) | testosterone, oestradiol, progesterone inhibit GnRH lowers FSH and LH |
| Positive feedback (hormone feedback loops) | high sustained E2 in females triggers LH surge Feedback ensures balance in reproductive cycle and prevents overstimulation |
| Environmental influences on Reproduction | stress nutrition daylight/photoperiod metabolic state |
| Luteolysis | regression of CL |
| Components of luteolysis | functional regression: loss of progesterone secretion structural regression: physical breakdown of luteal tissue |
| Puberty | the ability of the animal to produce gametes and reach reproductive competence |
| When does puberty occur? | when GnRH neurosecretory activity increases |
| Female puberty definition | age at first behavioural oestrus (heat) age at which the female can support a pregnancy |
| Male definition of puberty | age when behavioural traits first expressed (mounting/erection) age at first ejaculation age when ejaculate contains threshold for spermatozoa fertilisation |
| Puberty timing | varies widely between species, breed, sex, growth rate and environment |
| Key mechanisms involved (neuroendocrine control of puberty) | reduced sensitivity to oestradiol negative feedback decline in oestradiol receptor-positive neurons in the hypothalamus increased kisspeptin neuron activity stimulating GnRH neurons |
| GnRH pulsatility triggers (neuroendocrine control of puberty) | increased LH surges follicular growth oocyte maturation first ovulation |
| Factors affecting puberty | nutrition breed differences photoperiod social interactions (male exposure advances puberty) stress and environmental conditions |
| Silent ovulation | first ovulation often occurs without behavioural oestrus CL forms; progesterone primes brain for later normal oestrus cycles |
| Oestrus cycle purpose | synchronise ovulation and receptivity with optimal embryo survival environment |
| Oestrus categories | polyestrous seasonally polyestrous monoestrus |
| Proestrus | begins after CL regression and ends at onset of estrus, period of follicle growth |
| Oestrus | period of sexual receptivity "heat" |
| Metestrus | early postovulatory period, CL begins to develop |
| Diestrus | begins approx 4 days after ovulation and ends with regression of CL |
| Stages of oestrus cycle | Proestrus oestrus metestrus diestrus |
| seasonal polyestrous cycles | only occur during certain times of the year |
| long day breeders cycle | breed when day length increases eg horses |
| short day breeders cycle | breed when day length decreases eg sheep |
| Monoestrus | one cycle per year oestrus periods last for several days eg dogs |
| Polyestrous | regularly occurring oestrus cycles throughout the year eg cattle and swine |
| Ovulation | release of egg from ovary occurs near the end of the oestrus period varies between species |
| before ovulation | egg cell contained in a follicle |
| during ovulation | follicle breaks, releasing egg into oviduct if sperm present, egg may become fertilised |
| after ovulation | CL forms on ovary and releases progesterone if egg not fertilised, CL does not grow, allowing another follicle to grow and another oestrus period to occur |
| Progesterone functions | prepares uterus for embryo implantation stops other eggs from forming maintaining pregnancy mammary gland development |
| Cow gestation | 283 days |
| Cow oestrus | 10-26 hours 18 hour average |
| Cow oestrus cycle | 18-24 days 21 day average |
| Cow ovulation | 4-16 hours post oestrus |
| Sheep gestation | 150 days |
| sheep oestrus | 20-42 hours 30 hour average |
| sheep oestrus cycle | 15-18 days 17 day average |
| sheep ovulation | 12-18 hours post oestrus |