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ANSC4045 - week 4
farm animal repro - hormonal control + onset of puberty
| Term | Definition |
|---|---|
| hypothalamus | • specialized ventral portion of the brain • hypothalamic nuclei: groups of nerve cell bodies |
| hypothalamo-hypophyseal portal system | • allows minute quantities of releasing hormones to act on the anterior pituitary before being diluted by the general circulation • nerve endings from surge + tonic centers terminate at blood vessels here |
| portal system | • delivery of hormone or regulatory molecule from one tissue to another without entering general circulation |
| hormones | • produced by a gland and act on a target tissue through specific receptors • relatively short half-lives |
| positive feedback in hormonal control | • hormone stimulates target tissue to produce a substance --> this substance stimulates production of more of the original hormone • ex: FSH + LH --> estrogen from follicle --> GnRH from hypothalamus --> LH surge --> ovulation |
| negative feedback in hormonal control | • hormone stimulates target tissue to produce a substance --> this substance inhibits production of the original hormone • ex: LH stimulates ovary to produce progesterone --> decreases GnRH, FSH, and LH production --> incomplete follicular development |
| three ways to classify hormones | 1. source 2. mode of action 3. biochemical classification |
| reproductive hormones from the hypothalamus | • releasing factors |
| reproductive hormones from both pituitary lobes | • gonadotropins, somatotropin, prolactin, oxytocin |
| reproductive hormones from the gonads | • steroids |
| reproductive hormones from the uterus | • prostaglandins, steroids |
| reproductive hormones from the placenta | • steroids, others |
| actions of reproductive releasing hormones | • stimulate the release of other hormones |
| actions of reproductive gonadotropins | • stimulate the gonads |
| actions of reproductive steroids | • sexual promotion |
| other actions of reproductive hormones | • pregnancy maintenance • luteolysis: destruction of corpus luteum |
| biochemical structure of peptide hormones | • chain of less than 20 amino acids |
| biochemical structure of protein hormones | • chain of more than 20 amino acids |
| biochemical structure of steroid hormones | • 4 carbon ring core: cyclopentanoperhydrophenanthrene |
| biochemical structure of prostaglandins | • 20 carbon unsaturated fatty acids |
| peptide hormones | • hypothalamic + releasing hormones • neuropeptides: GHRH + GnRH, produced by neural cells in small quantities, short half lives |
| protein hormones | • prolactin: non-glycosylated, single polypeptide chain • relaxin: non-glycosylated, two-chain polypeptide • glycoproteins: glycosylated --> more stable + longer half life; FSH + LH + TSH share similar structure |
| similar structures of glycoproteins | • FSH + LH + TSH • alpha subunit is common among the three hormones but beta subunit is unique for each one |
| steroid hormones | • four carbon rings A, B, C, D • synthesized from cholesterol: multistep pathway, common intermediates |
| transformation of cholesterol to estradiol | • cholesterol --> pregnenolone --> progesterone --> testosterone --> estradiol • each step occurs by an enzymatic conversion |
| prostaglandins | • F2-alpha + E2: partial control of ovulation • 20-carbon unsaturated fatty acids derived from arachidonic acid • short half-lives |
| action of prostaglandin F2-alpha | • luteolysis: destruction of corpus luteum |
| three domains of a transmembrane receptor | 1. extracellular domain 2. transmembrane domain 3. intracellular domain |
| cAMP second messenger system | • protein hormones interacts with cell surface receptor • triggers G protein --> adenylate cyclase --> cAMP --> protein kinases |
| slow response action | • primary mode of action for steroid hormones • steroid diffuses through cell membrane --> cytoplasmic receptor --> new protein products |
| three patterns of reproductive hormonal secretion | 1. episodic / fast: fast spurts of large amounts of hormone 2. basal / background: consistent hormone production with small fluctuations 3. sustained / consistent: gradual increase |
| metabolism of steroid hormones | • metabolized by liver, excreted in urine + feces |
| metabolism of protein hormones | • degraded in liver + kidneys |
| metabolism of glycohormones | • longer half-life due to presence of carbohydrates |
| metabolism of steroid hormones | • metabolized more slowly than peptide + protein hormones |