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ANSC4045 - week 4

farm animal repro - hormonal control + onset of puberty

TermDefinition
hypothalamus • specialized ventral portion of the brain • hypothalamic nuclei: groups of nerve cell bodies
hypothalamo-hypophyseal portal system • allows minute quantities of releasing hormones to act on the anterior pituitary before being diluted by the general circulation • nerve endings from surge + tonic centers terminate at blood vessels here
portal system • delivery of hormone or regulatory molecule from one tissue to another without entering general circulation
hormones • produced by a gland and act on a target tissue through specific receptors • relatively short half-lives
positive feedback in hormonal control • hormone stimulates target tissue to produce a substance --> this substance stimulates production of more of the original hormone • ex: FSH + LH --> estrogen from follicle --> GnRH from hypothalamus --> LH surge --> ovulation
negative feedback in hormonal control • hormone stimulates target tissue to produce a substance --> this substance inhibits production of the original hormone • ex: LH stimulates ovary to produce progesterone --> decreases GnRH, FSH, and LH production --> incomplete follicular development
three ways to classify hormones 1. source 2. mode of action 3. biochemical classification
reproductive hormones from the hypothalamus • releasing factors
reproductive hormones from both pituitary lobes • gonadotropins, somatotropin, prolactin, oxytocin
reproductive hormones from the gonads • steroids
reproductive hormones from the uterus • prostaglandins, steroids
reproductive hormones from the placenta • steroids, others
actions of reproductive releasing hormones • stimulate the release of other hormones
actions of reproductive gonadotropins • stimulate the gonads
actions of reproductive steroids • sexual promotion
other actions of reproductive hormones • pregnancy maintenance • luteolysis: destruction of corpus luteum
biochemical structure of peptide hormones • chain of less than 20 amino acids
biochemical structure of protein hormones • chain of more than 20 amino acids
biochemical structure of steroid hormones • 4 carbon ring core: cyclopentanoperhydrophenanthrene
biochemical structure of prostaglandins • 20 carbon unsaturated fatty acids
peptide hormones • hypothalamic + releasing hormones • neuropeptides: GHRH + GnRH, produced by neural cells in small quantities, short half lives
protein hormones • prolactin: non-glycosylated, single polypeptide chain • relaxin: non-glycosylated, two-chain polypeptide • glycoproteins: glycosylated --> more stable + longer half life; FSH + LH + TSH share similar structure
similar structures of glycoproteins • FSH + LH + TSH • alpha subunit is common among the three hormones but beta subunit is unique for each one
steroid hormones • four carbon rings A, B, C, D • synthesized from cholesterol: multistep pathway, common intermediates
transformation of cholesterol to estradiol • cholesterol --> pregnenolone --> progesterone --> testosterone --> estradiol • each step occurs by an enzymatic conversion
prostaglandins • F2-alpha + E2: partial control of ovulation • 20-carbon unsaturated fatty acids derived from arachidonic acid • short half-lives
action of prostaglandin F2-alpha • luteolysis: destruction of corpus luteum
three domains of a transmembrane receptor 1. extracellular domain 2. transmembrane domain 3. intracellular domain
cAMP second messenger system • protein hormones interacts with cell surface receptor • triggers G protein --> adenylate cyclase --> cAMP --> protein kinases
slow response action • primary mode of action for steroid hormones • steroid diffuses through cell membrane --> cytoplasmic receptor --> new protein products
three patterns of reproductive hormonal secretion 1. episodic / fast: fast spurts of large amounts of hormone 2. basal / background: consistent hormone production with small fluctuations 3. sustained / consistent: gradual increase
metabolism of steroid hormones • metabolized by liver, excreted in urine + feces
metabolism of protein hormones • degraded in liver + kidneys
metabolism of glycohormones • longer half-life due to presence of carbohydrates
metabolism of steroid hormones • metabolized more slowly than peptide + protein hormones
Created by: junoreg
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