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Clin Path Quiz 10/11

Lecture 11: Muscle DIsease/Injury

QuestionAnswer
skeletal muscle voluntary, striated muscle that moves the bones of the skeleton
cardiac muscle involuntary, striated muscle
smooth muscle involuntary, nonstriated muscle, found in the GI tract
types of diseases detected trauma, exertion, degenerative myopathies, inflammation, nutritional myopathies, ischemic myopathies, metabolic myopathies
myopathies diseases of the muscle; white muscle disease, saddle thrombus, exertional rhabdomyolysis
muscle disease/damage monitor leakage of enzymes that originate from increased activity in the muscle, increase of enzymes is related to the number of myocytes injured, NOT the severity of the injury
creatine kinase (CK) cellular enzyme in muscle cells, drives the reaction that leads to energy storage in muscle, can be used to check for brain damage; major enzyme that indicates muscle damage when found in blood
increases in CK very SPECIFIC and SENSITIVE for skeletal and muscle damage, dramatic increases >20x reference interval
creatine kinase sample serum is preferred for some reference labs; false elevation could be due to hemolysis, needs to be evaluated quickly b/c it is not very stable
causes of CK increase muscle cell damage via IM injections, extreme exercise, persistent recumbency, myopathies, electric shock, hypothermia
aspartate aminotransferase (AST) found in most tissues, especially hepatocytes, skeletal muscle and cardiac muscle, erythrocytes
increase in AST AND CK most consistent wtih myopathy
AST increase WITHOUT CK more suspicious activity
lactate dehydrogenase (LDH) found in many tissues (skeletal and cardiac muscles, liver, kidney, erythrocytes); little clinical use for total LDH (not very specific)
LDH increase does NOT rule in any one disorder or organ that is damaged
Created by: mkroon26
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