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Clin Path Bonus Quiz
Lecture 9: Thrombocytes
| Question | Answer |
|---|---|
| thrombocytes | platelets, stain light purple/blue with dark purple granules, have a lifespan of 5-10 days |
| megakaryocyte | giant, multi-nucleated cell, large amount of cytoplasm |
| hemostasis | the process by which blood is prevented from leaking out of damage blood vessels (CLOTTING) |
| how does hemostasis occur? | platelets will be attracted to the injury, then will stick together as proteins in the blood are activated to form the clot; a platelet plug will form around the torn vessel |
| normal canine platelet count | 250000-500000/uL |
| thrombocytopenia | decreased platelet count, <250000/uL |
| thrombocytopenia causes | increased destruction (Rickettsial infection, immune mediated), decreased production (Aplastic anemia), increased use (hemorrhage), artifact due to clot formation prior to testing |
| thrombocytopenia clinical signs | clinical signs may not be seen immediately due to storage of platelets in the spleen; slow clotting times, unexplained bruising (indicates bleeding subcutaneously) |
| petechia | small pinpoint bruising |
| ecchymoses | large area of bruising |
| thrombocytosis | not usually a clinically significant problem, may be seen in response to trauma or hemorrhage |
| microplatelets | smaller than normal |
| macroplatelets | large or MEGA platelets, usually due to increased production by the bone marrow |
| infectious granules | large granules in the platelets, especially seen in dogs |
| example of infectious granules | Anaplasma platys; a tick-borne bacteria that infects the platelets which leads to their destruction by the immune system |
| automated platelet count pros | rapid results, extremely efficient |
| automated platelet count cons | may be less accurate if platelet clumping has occurred |
| EPC manual platelet count | estimated platelet count; count the platelets in 10 fields on oil immersion, average the platelet count and multiple by 15000 for platelets/uL |
| DIRECT manual platelet count | platelets are counted on hemocytometer; inaccurate due to similar appearance of platelets to debris |
| feline thrombocytes | appearance is similar to canine, but size is more variable; stain light purple/blue, granular appearance, large platelets may be noted in normal feline blood |
| normal feline platelet count | 300000-700000/uL |
| where do you check for platelet clumps? | along the feathered edge |
| is platelet clumping common in cats? | yes, but is more likely due to artifact, not actual differences in cat and dog platelets |
Created by:
mkroon26
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