Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
RATS Quiz 1, Part 2
The Mouse, Lecture 2
| Question | Answer |
|---|---|
| Laboratory Mouse | Mus musculus, adults weigh between 25 and 40 g |
| Outbred stocks | unique and heterogenous, maintained in large populations |
| Inbred strains | nearly genetically identical; common strains: C57BL, BALB/c, C3H; common mutant strains: nude, SCID |
| 2 methods used to produce transgenic mice | pronuclear injection, gene targeting |
| gnotobiotic | known associated microflora |
| barbering | removal of hair and whiskers from faces, heads, and bodies of other mice, skin has no wounds |
| stomach | divided into nonglandular forestomach and glandular stomach |
| sexing is done by | anogenital distance |
| dental formula | 2 (I 1/1, C 0/0, P 0/0, M 3/3) |
| incisors | grow continuously throughout life |
| estrous cycle is | 4-5 days |
| monogamous breeding systems | one male, one female |
| polygamous breeding systems | one male, multiple females; maximizes production and space utilization |
| sexual maturity | 6-8 weeks of age (~20-30 g) |
| Whitten effect | synchronization of estrus; large groups of females housed together and then exposed to male odor |
| Bruce effect | aborting pregnancy; recently bred female exposed to strange male |
| Lee-Boot Effect | large groups of females housed together without male exposure leads to suppressed estrus cycle |
| cannabalism | occurs if high-pitched sounds, little nesting material, or if disturbed |
| gestation | 19-21 days |
| pups | fur and ears open by day 10, eyes open at day 12, eat solid food at 2 weeks, weaned at 21 days |
| minimum cage height | 5 inches |
| mice consume | 4-5 g of solid food per day |
| mice drink | 6-7 mL of water per day |
| to restrain | grasp base of tail, allow mouse to cling to something, grab scruff, lift mouse and secure tail between pinky finger and palm of same hand |
| blood collection | up to 10% of circulating blood volume can be withdrawn every 2-4 weeks |
| blood withdrawal sites | facial vein, retro-orbital sinus, lateral saphenous vein, submental region, cardiac puncture |
| urine collection | mice can be stimulated to urinate upon handling or placement on cold surface |
| pneumonia and respiratory | bacterial disease, Mycoplasma pulmonis; clinical signs: teeth chattering, labored respirations, weight loss, conjunctivitis |
| Helicobacter infection | bacterial disease, inhabit GI tract from stomach to colon in variety of species, transmission via FECAL-ORAL |
| H. bilis, H. hepaticus documented pathogens | bacterial disease associated w/ chronic active hepatitis, hepatic neoplasia, inflammatory bowel disease, proliferative colitis, rectal prolapse; clinical signs normally not seen until liver disease is end stage |
| Tyzzer's disease | bacterial disease caused by Clostridium piliforme; clinical sings include diarrhea, dehydration, anorexia |
| Transmissible Murine Colonic Hyperplasia | bacterial disease caused by Citrobacter rodentium; clinical sings include diarrhea, retarded growth, ruffled fur, soft feces |
| Corynebacterium Kutscheri | bacterial disease, produced pseudotuberculosis in stressed or immunocompromised mice |
| Salmonella spp. | bacterial disease, rare problem, but significant because of zoonotic potential |
| Streptobacillus moniliformis | bacterial disease, not common, but one of the causes of rat-bite fever |
| signs of illness | lack of grooming, dull haircoat, decreased activity, hunched, soft feces, barbering |
| parvoviruses | viral disease, small, non-enveloped DNA viruses |
| 2 parvoviruses known to infect laboratory animals | Mouse Parvovirus (MPV), Mouse Minute Virus (MMV) |
| MPV | of greater concern, causes immune dysfunction and can infect lymphoid tissue, transmission via FECAL-ORAL |
| Mouse Hepatitis Virus (MHV) | highly contagious coronavirus, transmission via CIRECT CONTACT, FOMITES, AIRBORNE PARTICLES; clinical signs include severe diarrhea, runting, empty stomach, high mortality, encephalitis with tremors |
| Epizootic Diarrhea of Infant Mice (EDIM) | rotavirus that causes diarrhea in suckling mice less than 2 weeks of age; clinical signs include soft, yellow feces or accumulation of dried feces around anus, affect mice continue to nurse |
| Murine Norovirus (MNV) | common viral infection in laboratory mice, affect the immune system |
| Sendai Virus | highly contagious parainfluenza-1 virus, rarely seen, can cause clinical respiratory disease; AEROSOL transmission |
| Murine Retroviral Infection | Murine leukemia virus (MuLV), Murine mammary tumor virus (MuMTV) |
| Pneumonia Virus of Mice (PVM) | pneumovirus that replicates in the respiratory tract |
| Ectromelia | Poxvirus, clinical signs include conjunctivitis, pox-like rash; severe infection of feet and tail can lead to amputation |
| Mites | infestation can induce immunologic changes, diagnosis via skin scrapings, fur plucks, and cellophane tape to fur; eradication via Ivermectin or surgical rederivation |
| Pinworms | Syphacia oblevata and Aspiculuris tertraptera in habit the cecum and colon, NOT transmissible to humans |
| Lice | highly uncommon in laboratory mice |
| Tapeworms | Rodentolepid nana and Hymenolepis diminuta; R. nana is a public health concern as intermediate host is not needed for human infection |
| Flagellates | Spironucleus muris and Giardia muris occur in small intestine and cecum |
| Neoplasia | mammary tumors, most are adenocarcinomas; lymphomas |
| bite wounds | common wound locations are tail, perineum, back, shoulders, and head |
| Ulcerative Dermatitis | genetically linked skin syndrome, lesions most common over dorsal, cervical, and scapular regions |
| Malocclusion | overgrowth on incisors can lead to emaciation and death |
| euthanasia | CO2 is commonly used, but causes more pain and suffering; neonates under 10 days show resistance to CO2 |
Created by:
mkroon26
Popular Veterinary sets