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Organophosphates
Question | Answer |
---|---|
Organophosphate MOA | noncompetitive inhibition of acetylcholinesterase |
OP toxicity signs | Muscarinic signs: dyspnea, bradycardia, micturition, miosis, GI signs. Similar to pyrethrin toxicity signs Nicotinic signs: SkM weakness, CNS signs (dizziness) CNS signs: ataxia, depression |
OP toxicity cause of death | respiratory failure |
OP toxicity lesions | non-specific, non-conclusive |
OP toxicity treatment | atropine to decrease muscarinic effects, 2-PAM unless it's carbamate toxicity! |