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The Pancreas
fx, enzymes, tests-clin path
Question | Answer |
---|---|
2 main functions of pancreas? | exocrine and endocrine |
exocrine fx | acinar cells; secrete digestive enzymes; 98% of the pancreas is made of these |
endocrine fx | islet of langerhans; insulin secreation; 1-2% made up of pancreas |
what is the islet of langerhans? | cluster of cells embedded in acinar cells thru out pancreas |
secretion of digestive enzymes: | trypsin, chymotrypsin-for protein digestion |
amylase is? | polysaccharide digestion |
lipase is? | lipid digestion |
pancreatic trypsin inhibitor is? | protects against autodigestion |
bicarbonate is? | neutralizes gastric acid |
antibacterial factors are? | inhibit intestinal bacteria |
pancreatitis forms how? | when enzymes are activated within the pancreas resulting in autodigestion |
predisposing factors? | obesity and long term high fat intake |
clinical signs? | praying position |
diagnose how? | amylase and lipase are usually elevated-indicating a leak of enzymes, ultrasound- gives specific dx in dog, Spec cPLI |
what is spec cpli? | specific canine pancreatic lipase immunoassay |
acute pancreatitis tx? | maintain pancreatic perfusion-ivfl, reduce pancreatic secretion, relieve pain |
what is epi? | exocrine pancreatic insuffiency |
what happens? | progressive loss of acinar tissue from atrophy or inflammatory destruction-pancreas shrinks |
clinical signs of epi? | weight loss and diarrhea |
what is borborygmus? | gassey |
how to diagnose epi? | serum trypsin-like immunoreactivity assay (TLI) |
what does amylase do? | breaks down starchs |
where does amylase come from? | excreted by kidneys, released by pancreas |
what does lipase do? | break down fats |
what does glucagon do? | increase blood glucose |
what does insulin do? | decreases blood glucose |
gluconeogenesis means? | producing new sugar |