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hepatic fx analysis
clin path
| Question | Answer |
|---|---|
| largest internal organ? | liver |
| hepatic function | conjugation and excretion of bilirubin and bile acids |
| what are sinusoids? | vascular channels |
| list hepatic blood flow | sinusoids to central vein to hepatic vein to caudal vena cava |
| 3 vessels that supply blood? | hepatic artery, hepatic vein, and portal vein |
| what is a liver lobule and what is it made of? | a section of hepatocytes |
| what is a bile canaliculi? | canals b/n hepatocytes where blood flows toward hepatic vein and bile away from |
| what are kupffer cells? | macrophages lining venous sinusoids |
| microhepatica? | small liver |
| hepatomegaly? | enlarged liver |
| hepatic encephalopathy? | increased levels of blood ammonia causing severe behavioral changes; portosystemic shunt and the liver can cause this brain disease |
| icterus? | yellow discoloration of serum/plasma |
| jaundice? | yellow discoloration of skin |
| hepatic lipidosis? | fatty liver |
| what is alt? | alanine aminotransferase |
| what causes an increase in alt? | hepatocellular damage from any cause |
| what is sap or alkp? | serum alkaline phospatase/ alkaline phospatase |
| about sap/alkp? | not liver specific; young animals commonly have increased levels |
| cholestasis? | blocked gall bladder |
| serum is plasma without what? | fibrinogen |
| what is asp? | aspartate aminotransferase |
| about asp? | shorter half life than alt and may indicate strenous exercise |
| what is ggt? | gamma glutamyltranspeptidase |
| about ggt? | elevated w/ obstructive liver disease |
| liver disease may impair what? | ammonia detoxification |
| bilirubin is a waste product when? | rbc lyses |