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VET 150 Week 3
Drugs used in the Nervous System
| Question | Answer |
|---|---|
| Central Nervous System | Brain & Spinal cord Control center of the entire nervous system |
| Peripheral Nervous System | Divided into two main parts: Autonomic and Somatic |
| Somatic | Efferent nerves that carry impulses from the CNS to the skeletal muscle tissue Voluntary, under conscious control |
| Autonomic | Efferent nerves that carry information from the CNS to the cardiac muscle, glands, smooth muscle Involuntary, unconscious control 2 Subdivisions: Sympathetic Nervous System & Parasympathetic Nervous System |
| CNS drugs act by ______ or blocking the effects of neurotransmitters. | mimicking |
| Parasympathetic Nervous System | "Rest & restore" regulates energy-conserving activities Cholinergic Receptors: Nicotinic, Muscarinic Neurotransmitter: Acetylcholine |
| Sympathetic Nervous System | "Fight or Flight" regulates energy-expanding activities Adrenergic Receptors: a1, a2, b1, b2 Neurotransmitters: Epinephrine, Norepinephrine, Dopamine |
| Alpha 1 | Arterioles, urethra, eye |
| Alpha 2 | Skeletal Muscles |
| Beta 1 | Heart, kidneys |
| Beta 2 | Skeletal blood vessels, bronchioles |
| Dopaminergic | Kidneys, heart, mesenteric blood vessels |
| Cholinergic | parasympathominmetics |
| Cholinergic blocking agents | anticholinergics, parasympatholytics |
| Adrenergic agents | sympathomimetics |
| Adrenergic blocking agents | sympathlytics |
| Cholinergic Agonists | Drugs that stimulate cholinergic receptor Used to diagnose myasthenia gravis Reduce IOP in glaucoma |
| Acetylcholine | Seldom used, rapidly broken down by AChE |
| Carbamylcholine | Treats GI atony, stimulate uterine contractions in pigs |
| Bethanechol | Treats GI & urinary tract atony |
| Pilocarpine | Reduces IOP |
| Metoclopramide (Reglan) | Control vomiting, promote GI emptying |
| Edrophonium (Tensilon) | Used to diagnose myasthenia gravis |
| Pyridostigmine | Treatment of myasthenia gravis |
| Neostigmine | Treats urine retention, GI Atony, antidote to neuromuscular blocking agents |
| Physostigmine | same uses as neostigmine |