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Pharmacology
Chapter 10 Drugs Used in Ophthalmic and Otic Disorders
Question | Answer |
---|---|
Describe clinical indications for common ophthalmic agents. | diagnostics, anesthetics during examinations, glaucoma, cataracts, corneal infections, endophthalmitis, uveal disease, allergies, inflammation, eye pain, conjuncitvitis, fungal infections, feline ocular herpes, KCS, dry eyes |
Describe clinical indications for use of otic agents. | cerumen/purulent exudate in ears, ear infections, acute/chronic otitis, otic candidiasis, otacariasis. |
What is fluorescein sodium? | a stain used on the cornea when a corneal ulcer is suspected. An ulcer can be observed w/ a cobalt blue filter & light source. Also used to diagnose patency of nasolacrimal outflow duct. |
What is lissamine green used for? | To diagnose corneal damage & quantify tear production. |
What is phenol red thread used for? | evaluate tear production. |
What is Rose Bengal? | used to detect viral keratitis in felines; corneal epithelium evaluation for keratoconjunctivitis sicca (KCS). May be toxic, thoroughly flush from eye after exam to prevent irritation. |
Describe ocular anesthetics. | used during tonometry or to relieve corneal pain during examination. |
What agents are used to decrease intra-ocular pressure (IOP)? | sympathomimetics (alpha2-agonists); beta-adrenergic antagonists; prostaglandins; others. |
Describe osmotic agents in regards to ophthalmic conditions. | Osmotic agents increase osmotic pressure of plasma, which draws fluid out of the intraocular envrionment. Only for acute episodes of glaucoma; not for maintenance. |
What are mydriatic cycloplegic vasoconstrictors? | They cause the sphincter of the iris and ciliary muscles to relax. Used to induce mydriasis and cycloplegia for diagnostic purposes. |
How do anti-inflammatory/analgesic ophthlamic agents help with eye conditions? | Used to treat allergic conjunctivitis, seasonal allergies. |
Describe the use of NSAIDs in ophthalmic conditions. | help the cornea to heal, treat allergic conjunctivitis. |
List reasons to use steroidal anti-inflammatory agents. | treat diseases of the eye that may include conjunctiva, sclera, cornea & anterior chamber. Maximum results occur with frequency increases rather than increased concentrations of drug. |
What are ophthalmic analgesics used for? | Eye pain relief. |
What is antimicrobial ophthalmic therapy? | treatment and management of ocular disease (corneal infections, endophthalmitis, superficial corneal ulcers, keratitis, bacterial infections). |
What are anticollagenase agents? | Agents that stop melting effect of collagenases and proteases on the cornea. |
What are uses of ocular lubricants/artificial tear products? | dry eyes, relieve eye irritation, during anesthetics to keep eyes lubricated. |
List some otic drugs. | cerumenolytic agents--remove ear wax; cleaning/drying--prevent infections; antiseptic--heal ear infections; antibiotic potentiating agents--use in middle ear; corticosteroids-otitis; antibacterials; antifungals; antiparasitic |
What are possible adverse reactions and contraindications of commonly used agents? | eye irritation, miosis, hypersalivation, mydriasis, photophobia, allergies, accommodation paralysis, corneal epithelial damage. Some not for use in pregnant animals, NSAIDs not for corneal ulcers or hypersensitivity problems. |