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Pharmacology
Chapter 5 Drugs Used in Respiratory System Disorders
| Question | Answer |
|---|---|
| Describe the basic anatomy & physiology of the respiratory system. | It is the lungs and the passageways that carry air to and from them. Nostrils, nasal cavity (turbinates), pharynx, larynx, trachea (becomes left/right bronchi), bronchi, bronchioles, alveoli (surrounded by capillaries). Passageways to lungs= upper system |
| List the protective mechanisms of the respiratory system. | hairs in turbinates (nasal cavity); mucous membranes; cilia in upper respiratory tract; protective reflexes (cough, sneeze, laryngospasm, bronchospasm). |
| Describe the principles for treating respiratory issues. | Control secretions--decrease production/increase elimination (make less viscid or remove cause); control reflexes--ex. nonproductive cough; maintain normal airflow-- remove constriction, edema, mucous; oxygen therapy. |
| Explain the purpose of expectorants. | Liquefy & dilute sticky(viscid) secretions, which helps to eliminate them. Used for productive coughs. |
| What are mucolytics used for? | To decrease the viscosity of respiratory secretions by altering chemical compounds of mucus. Administered by nebulization. |
| Describe antitussives. | They inhibit or suppress coughing. They are centrally acting--depress the cough center in the brain; peripherally acting (lozenges or drops) not used in veterinary medicine. |
| Describe the action of bronchodilators. | Reverse the constriction of airways; four categories: cholinergic blockers--prevent acetylcholine's effects antihistamines Beta2 adrenergic agonists-relax smooth muscle & reduce histamine methylxanthines--allow AMP to accumulate (promotes dilation) |
| What are antihistamines used for? | They block the effects of histamine (allergic reactions); more effective when used as a preventative. They don't displace histamine that has already combined with a receptor. |
| What is the mechanism of action of decongestants? | They reduce the congestion of nasal membranes by reducing swelling. |
| What are potential uses for respiratory stimulants? | Stimulate respiration before & after anesthesia; speed awakening & restoration of reflexes after anesthesia; stimulate neonatal animals after dystocia or c-section. |
| What are the advantages of inhalant therapy? | High concentrations of medications are delivered into the airways while limiting their levels in the blood, which reduces the chance of a toxic reaction. |
| What are the disadvantages of inhalant therapy? | Efficacy depends on the dose and how well it is distributed in the lungs; size of particles may affect distribution of medication; airway pathology may interfere with distribution. |