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L6 - Autacoid Pharm

Clin Pharm Ex1

QuestionAnswer
Histamine can be synth by... Basophils & platelets, mast cells, & enterochromaffin-like cells
Histamine utilizes what kind of receptors? GPCR
Enterchromaffin cells are found in... epithelium of GI & resp tracts
Red spot cutaneous vasodilation
Flare arteriolar dilation as a result of stimulation of sensory nerve endings
Wheal edema
Histamine 1 receptors mediate... inflmtn, smooth m contr, wound healing, pain, etc.
Histamine 2 receptors mediate... stomach acid secretion
Histamine 3 receptors mediate... vestibular pathophysiology
1st Gen H-1 Antihistamine ex: Diphenhydramine, Hydoxyzine, Chlorpheniramine, & Meclizine
2nd Gen H-2 Antihistamine ex: Loratadine, Cetirizine, & Fexofenidine
How do 2nd gen antihistamines differ from 1st gen? no sedation & longer duration
H1 blockers are not as effective against atopic dermatitis as... Cytokine blockers
Cytokine blocker ex: Cyclosporin & Oclacitinib
Cytopoint targets what factor to tx atopic dermatitis? canine IL-31
H2 blockers treat... peptic ulcers (horses), gastroesoph reflux, & GI protection from NSAIDs
H2 blocker ex: Famotidine & Ranitidine
H3 blocker ex: Betahistine, Icatibant, & Ecallantide
H3 blocker, tx motion sickness, & vestibular dysfxn in cats & dogs Betahistine
Betahistine can also be used to... ↓ appetite & ↑ wakefulness
Inflmtry mediator: mediates pain, ↑ vasodilation, & smooth m contr, Bradykinin
Bradykinin B2 blocker that tx acute angioedema Icatibant
Kallikrein inhib = prev Bradykinin release Ecallantide
Ecallantide can be used to tx acute attacks of angioedema
Created by: Dr_B.Phillips22
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