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TGE of Swine

Coronaviridae

QuestionAnswer
TGE = Transmissible Gastroenteritis
One of the major causes of death in young piglets because of two major clinical signs: Diarrhea and Vomiting
Hosts: Swine, Dogs and cats (up to 2 weeks)
Antigenically related to: Canine coronavirus and feline coronavirus
Characteristics of Porcine Respiratory Coronavirus (PRC): deletion mutant of the virus causing TGE; mutant lost its enterotropism and has acquired affinity for the respiratory tract
Transmission: Within a herd: Fecal-oral. Herd to Herd: newly introduced animals (feeder pigs). Dogs, cats, foxes, and starlings
Infecetd pigs shedding timeline: 2-3 weeks
Chronic carrier pigs shedding timeline: up to 10 weeks
Morbidity: approaches 100%
Pathogenesis: Acid kills the virus but the piglets stomachs aren't as acidic as adults so the virus survive and reeks havoc on the VILLOUS ENTEROCYTES of the SMALL INTESTINE = impaired digestion, accumulation of fluids in the intesting and diarrhea
Clinical Features of EPIDEMIC TGE: occurs after introduction into a seronegative herd. Inappetance, diarrhea, and vomiting.
Inversely related to age!
Mortality in pigs under 2 weeks with Epidemic TGE: near 100%
Clinical signs of Endemic TGE: persists in partially immune herds with frequent or continuous farrowings. Diarrhea. Mortality: 10-20%
How to differ from Rotavirus? LAB TESTS
Prevention and vaccination: Sows vaccinated with attenuated vaccines 3 weeks before farrowing to ensure high levels of colostral antibodies: there is NO VIREMIA
Created by: lkollmeier
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