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Paramyxoviridae
Bovine Respiratory Syncytial Disease. Genus Pneumovirus
Question | Answer |
---|---|
What is special about this genus? | NO hemagglutin-neuraminidase protein and produce Intracytoplasmic inclusion bodies |
Hosts: | Cattle and Sheep |
Properties of the virus? | Cross-protection. Extremely fragile. Termolabile and sensitive to freeze-thaw cycles. SPECIMENS SHOULD NOT BE FROZEN |
Transmission: | Aerosolization. Persists in herd via CARRIERS |
What is an important factor of the pathogenesis of this virus? | Complete loss of the ciliated epithelium so there can be a secondary bacT infection |
Clinical features: | Acute, mild, inapparent. Incidence is highest in weaned calves and young cattle. URT INFECTION. |
Case Fatality rate? Morbidity? | usually low (3-5%) but can be high with secondary bacT infections causes severe bronchopneumonia. VERY HIGH (30-50% or higher) |
Immunity? | Short-lived and Multiple infections are common. Clinical disease is generally mild |
Diagnosis: | Virus isolation is VERY DIFFICULT because of the virus's fragility. Produces syncytia and inclusion bodies |