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Paramyxoviridae

Bovine Respiratory Syncytial Disease. Genus Pneumovirus

QuestionAnswer
What is special about this genus? NO hemagglutin-neuraminidase protein and produce Intracytoplasmic inclusion bodies
Hosts: Cattle and Sheep
Properties of the virus? Cross-protection. Extremely fragile. Termolabile and sensitive to freeze-thaw cycles. SPECIMENS SHOULD NOT BE FROZEN
Transmission: Aerosolization. Persists in herd via CARRIERS
What is an important factor of the pathogenesis of this virus? Complete loss of the ciliated epithelium so there can be a secondary bacT infection
Clinical features: Acute, mild, inapparent. Incidence is highest in weaned calves and young cattle. URT INFECTION.
Case Fatality rate? Morbidity? usually low (3-5%) but can be high with secondary bacT infections causes severe bronchopneumonia. VERY HIGH (30-50% or higher)
Immunity? Short-lived and Multiple infections are common. Clinical disease is generally mild
Diagnosis: Virus isolation is VERY DIFFICULT because of the virus's fragility. Produces syncytia and inclusion bodies
Created by: lkollmeier