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Canine Distemper. Genus Morbillivirus

What is special about this genus? NO hemagglutinin-neuraminidase protein! Intranuclear and intracytoplasmic inclusion bodies
What is another name for this disease? Hardpad Disease
Hosts: invaccinated dogs. Procyonidae[raccoons,panda]. Ursidae[bear]. Mustelidae[ferrets]. CNS infection in exotic Felidae
What is this virus related to? Measles and rinderpest viruses
What strains are HIGHLY virulent and neutrotropic? Snyder Hill, R252, and A75/17 strains
How resistant is this virus? EXTREMELY FRAGILE! Inactivated within a few hours at room temperature. Warm climates, after dog is removed, dies
Transmission and shedding? Inhalation of infected droplets. Found in all secretions from the 5th day after infection for up to 60-90 days
Virus multiplies in: Macrophages, Epithelial cells, T & B Lymphocytes (immunosuppression), and nervous tissue
Pathogenesis: Replication in cells of URT->LYMPHOCYTE-ASSOCIATED VIREMIA to reticuloendothelial system->more replication here->Lymphocyte&monocyte-associated secondary viremia
What is the antibody titer cutoff and number of days for the virus to stop spreading? >1:100 on the 8-9th day is GOOD. >1:100 not attained by the 14th day is BAD and the virus spreads throughout the body :(
Which strains cause polioencephalomyelitis? Demyelinating encephalomyelitis? Snyder Hill and A75/17. R252
What two late complications could be seen in old dogs? Harpad disease (hyperkeratosis of foot pads) & Old dog Encephalitis (virus persists in brain for more than 24 hours and causes damage after apparent recovery)
T/F. Most infections are subclinical. TRUE 50-70%. prevelance rate is in dogs between 3-6 months
Clinical signs in peracute cases? Acute cases? Mortality rate? rare. primarily respiratory or intestinal signs. 30-80%
What test can you use to diagnose the virus? Immunoperoxidase or FA staining of impression smears or conjunctiva or peripheral blood lymphocytes
Immunity? Survivors have LIFELONG immunity. Unpon exposure, dogs can be treated with HYPERIMMUNE SERUM or IMMUNE GLOBULIN
Schedule for puppy vaccination: modified-life vaccinse at 6 weeks. then at 2-4 week intervals until 16 weeks of age.
What is special about the modified-live vaccine? Canine morbillivirus and the human measles virus shares a common fusion protein antigen. Used only as a replacement for the first vaccinations in 6-12 week old pups. DO NOT GIVE TO PUPPIES UNDER 6 WEEKS! give IM
Created by: lkollmeier