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Newcastle Disease

There is only 1 serotype of this virus, but there are various strains. How are they differentiated and what are they? Vary depending on the cleavability and activation of their hemagglutinin-neuraminidase and fusion glycoproteins. Lentogenic. Mesogenic. Velogenic (Viscerotropic & Neurotropic)
How are the proteins in virulent strains cleaved and activated? Cellular proteases present in the tissues
Who plays host to this virus? Gallinaceous birds [domestic chickens, turkeys, guinea fowl, peacocks]. pigeons.
What two types of birds are highly RESISTANT to this disease? Canaries and Finches
Transmission? Aerosols and ingestion of contaminated food and water.
How long is the virus shed? Shed during incubation period, clinical stage, and limited periods during convalescence. Birds shed for up to 4 weeks after recovery. PERSISTENT CARRIER STATE
Location of replication? Mucosal epithelium of the URT and GIT
Discuss Viremias. Primary viremia spreads virus to the spleen and bone marrow->Secondary viremia leads to the virus to infect other organs like the lungs and CNS
Mucosal immunity is provided by ? whereas ? in the circulatory system blocks viremia. IgA. IgG
How soon can neutralizing Ab be detected [hemagglutination inhibition antibodies] and how long do they persist? within 4-6 days of infection. persists for at least 2 years
Clinical signs of Vicerotropic velogenic ND: peracute and LETHAL. Hemorrhagic and ulcer-like lesions in the GIT. Mortality approached 100% in ALL ages
Clinical signs of Neurotropic velogenic ND: Acute and LETHAL. Lesions in respiratory tract and CNS. *Hemorrhages are ABSENT* Mortality approaches 100%
Clinical signs of Mesogenic pathotypes: Acute respiratory and sometimes lethal nervous infection of young chickens. Mortality approaches 25%
Clinical signs of Lentogenic pathotypes: Mild to inapparents respiratory infection of chickens
Control? REPORTABLE. Quarantine and depopulation
Vaccination? Naturally occurring lentogenic strains [B1 or La Sota]. MATERAL Ab PROTECT BABY CHICKS FOR 3-4 WEEKS AFTER HATCHING.
Zoonotic: conjunctivitis
Created by: lkollmeier