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Retroviridae
Caprine Arthritis-Encephalomyelitis (CAE)
Question | Answer |
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What are the four main characteristics of this disease and which one is the most common form? | POLYARTHRITIS, Mastitis, Encephalomyelitis, and Interstitial pneumonia |
What is the main mode of transmission? | Colostrum and milk; kids infected at birth remain consistantly infected for life |
What cells is there a persistent infection of and why? What have chronic inflammatory changes in tissues been attributed to? | Monocytes and Macrophages. Ineffective neutralizingg antibody response because there is a CONTINUOUS EMERGENCE OF NEW ANTIGENIC VARIANTS. Immune complex hypersensitivity reactions |
Arthritis in goats is characterized by what? What resricts the movement of the goat? | Unilateral or bilateral swelling of mostly carpal joints [BIG KNEE]. Pain and thickening of the joint capsules [HYPERPLASTIC SYNOVITIS] |
What is the encephalomyelitis in this disease and what is it associated with? | Progressive leukoencephalomyelitis. Associated with paralysis and paresis. |
What are some clinical signs of a goat with encephalomyelitis? Are these signs reversible? | Afebrile, alert, good appetite, upward deviation of the head, paddling, and twisting of the neck. IRREVERSIBLE signs and the kids are usually euthanized |
Interstitial pneumonia is most seen in adults. What are the two signs associated with this? | Weight loss and respiratory distress because the intra-alveolar septa are thickened |
What is associated with indurative mastitis? | diffuse swelling of the mammary gland with firmness, fibrosis [HARD BAG or HARD UDDER] There is NO systemic illness |
What is the main diagnostic test for this disease? | Agar gel immunodiffusion test (AGID) |
What is a control method used for this disease? Can colostrum from CAEV-positive dams be used for other kids? | All kids must be removed from the dams at birth and given colostrum from virus-free dams. If no virus-free, can treat the positive colostrum at 56 degrees C for 1 hour |
How often are goats tested for this disease? What does a positive test indicate? | every 6 months. Indicates the goat is infected for life and will be a continual source for transmission of the virus |