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Retroviridae

Caprine Arthritis-Encephalomyelitis (CAE)

QuestionAnswer
What are the four main characteristics of this disease and which one is the most common form? POLYARTHRITIS, Mastitis, Encephalomyelitis, and Interstitial pneumonia
What is the main mode of transmission? Colostrum and milk; kids infected at birth remain consistantly infected for life
What cells is there a persistent infection of and why? What have chronic inflammatory changes in tissues been attributed to? Monocytes and Macrophages. Ineffective neutralizingg antibody response because there is a CONTINUOUS EMERGENCE OF NEW ANTIGENIC VARIANTS. Immune complex hypersensitivity reactions
Arthritis in goats is characterized by what? What resricts the movement of the goat? Unilateral or bilateral swelling of mostly carpal joints [BIG KNEE]. Pain and thickening of the joint capsules [HYPERPLASTIC SYNOVITIS]
What is the encephalomyelitis in this disease and what is it associated with? Progressive leukoencephalomyelitis. Associated with paralysis and paresis.
What are some clinical signs of a goat with encephalomyelitis? Are these signs reversible? Afebrile, alert, good appetite, upward deviation of the head, paddling, and twisting of the neck. IRREVERSIBLE signs and the kids are usually euthanized
Interstitial pneumonia is most seen in adults. What are the two signs associated with this? Weight loss and respiratory distress because the intra-alveolar septa are thickened
What is associated with indurative mastitis? diffuse swelling of the mammary gland with firmness, fibrosis [HARD BAG or HARD UDDER] There is NO systemic illness
What is the main diagnostic test for this disease? Agar gel immunodiffusion test (AGID)
What is a control method used for this disease? Can colostrum from CAEV-positive dams be used for other kids? All kids must be removed from the dams at birth and given colostrum from virus-free dams. If no virus-free, can treat the positive colostrum at 56 degrees C for 1 hour
How often are goats tested for this disease? What does a positive test indicate? every 6 months. Indicates the goat is infected for life and will be a continual source for transmission of the virus
Created by: lkollmeier