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Feline Immunodeficiency Disease

When was this virus discovered? Is there cross protection between subtypes? 1987. NO
Where is the virus mainly shed? How long is infection? SALIVA. Lifelong
What is the primary mode of transmission? Cat bites because the disease is mostly in free-raoming cat. ONE BITE is sufficient to transmit the virus
What is a second way of transmission other than saliva? in utero and postparturition to kittins via colostrum and milk
What is the hallmark of this disease pathogenetically? Progressive disruption of normal immune function and this subjects the cat to opportunisitic infections that KILL the cat
The virus has a tropism for 4 cell types: Helper T cells. Brain macrophages. Peritoneal macrophages. Astrocytes
What age range is this disease characteristic in? 3-5 years
What are the characterisitics of the Acute Phase of this disease? Asymptomatic or may show a transiently clinical signs. Ab can be detected by is ineffective at eliminating the virus
What characterisitics are seen in the latent phase? Asymptomatic and NO signs of illness are observed...Months to Years timespan
In the terminal phase, chronic infections are characterized by... clinical finding as a result of opportunisitc bacterial and fungal infections: chronic stomatitis and gingivitis, chronic respiratory disease, chronic diarrhea and wasting, dermatitis, neuro signs
When testing for Antibodies, how long after infection do they appear and how long to they last? within 2-4 weeks of infection and persist for life
What happens if cats are obtained in kittens less than 12 weeks old? The kittens must be retested after the age of 12 weeks to assure that antibodies detected were no maternally derived
What FIV core antigen is detected by ELISA? p24
Is this virus zoonotic? NO..it is species specific
Created by: lkollmeier