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Bovine Leukemia

Retroviridae

QuestionAnswer
What is another name for this disease? Enzootic bovine leukosis
This is a malignang neoplasm of what? Reticuloendothelial system of cattle
Dairy cattle infected vs. Beef cattle infected 10-50% vs. 1-20%
T/F. Free virus is often found in the blood. FALSE. It is rarely or never found in the blood. It is associated with B lymphocytes and is a v onc-
How is this disease transmitted? require close, prolonged contact. Primarily by the transfer of blood lymphocytes between animals. These lymphocytes are found in the blood, milk, and in tumor masses. Extremely small amounts are capable of transmitting the disease.
Is there biological transmission? NO
Vertical transmission accounts for a a very small proportion of infections (<10%). How does it occur? in utero or through colostrum and milk contining infected lymphocytes
What are the major target cells of this virus? B LYMPHOCYTES
There are 4 possible outcomes of the infection: (1)Failure of animal to be infected due to genetic resistance. (2)Asymptomatic infection and antibody response.(3)Persistent lymphocytosis with a benign proliferation of B lymphocytes. (4)Lymphosarcoma
How is an animal genetically resistant to persistant lymphocytosis? Has to do with the class II genes of the bovine major histocompatibility complex (BoLA). Cattle with the BoLA-Aw 7 are resistant and ones with the BoLA-Aw 12 are susceptible
How long do cattle who develop asymptomatic infections have before they are seropositive? 4-12 weeks after exposure
What percentage of animals develop the 3rd infectious possibility? ~33% of infected animals
What is the percentage of infected showing lymphosarcoma and what is the age group? 1-2% and they are between 4-8 years of age; 100% mortality
What are 3 common clinical signs observed? wieght loss, anorexia, and decreased milk production
What specific serological test can be used to detect this virus? Agar gel immunodiffusion test (AGID)
WHat does AGID test for? antibodies against the virus envelope glycoprotein gp51 and the major core protein p24
What age can you serologically test the cattle for the virus? over 6 months of age because you want to give time for the maternal antibodies to disappear
Created by: lkollmeier