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Bovine Leukemia
Retroviridae
| Question | Answer |
|---|---|
| What is another name for this disease? | Enzootic bovine leukosis |
| This is a malignang neoplasm of what? | Reticuloendothelial system of cattle |
| Dairy cattle infected vs. Beef cattle infected | 10-50% vs. 1-20% |
| T/F. Free virus is often found in the blood. | FALSE. It is rarely or never found in the blood. It is associated with B lymphocytes and is a v onc- |
| How is this disease transmitted? | require close, prolonged contact. Primarily by the transfer of blood lymphocytes between animals. These lymphocytes are found in the blood, milk, and in tumor masses. Extremely small amounts are capable of transmitting the disease. |
| Is there biological transmission? | NO |
| Vertical transmission accounts for a a very small proportion of infections (<10%). How does it occur? | in utero or through colostrum and milk contining infected lymphocytes |
| What are the major target cells of this virus? | B LYMPHOCYTES |
| There are 4 possible outcomes of the infection: | (1)Failure of animal to be infected due to genetic resistance. (2)Asymptomatic infection and antibody response.(3)Persistent lymphocytosis with a benign proliferation of B lymphocytes. (4)Lymphosarcoma |
| How is an animal genetically resistant to persistant lymphocytosis? | Has to do with the class II genes of the bovine major histocompatibility complex (BoLA). Cattle with the BoLA-Aw 7 are resistant and ones with the BoLA-Aw 12 are susceptible |
| How long do cattle who develop asymptomatic infections have before they are seropositive? | 4-12 weeks after exposure |
| What percentage of animals develop the 3rd infectious possibility? | ~33% of infected animals |
| What is the percentage of infected showing lymphosarcoma and what is the age group? | 1-2% and they are between 4-8 years of age; 100% mortality |
| What are 3 common clinical signs observed? | wieght loss, anorexia, and decreased milk production |
| What specific serological test can be used to detect this virus? | Agar gel immunodiffusion test (AGID) |
| WHat does AGID test for? | antibodies against the virus envelope glycoprotein gp51 and the major core protein p24 |
| What age can you serologically test the cattle for the virus? | over 6 months of age because you want to give time for the maternal antibodies to disappear |
Created by:
lkollmeier
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