click below
click below
Normal Size Small Size show me how
Gammaherpesvirinae
Malignant Catarrhal Fever (MCF)
Question | Answer |
---|---|
MCF is sportadic but highly fatal. What tissue does it primarily infect? | Lymphoid tissues and epithelial cells of the respiratory and GI tracts |
T/F. If there is no wildabeest or sheep contact, there is no need for vaccination. | TRUE |
Who are the hosts? | Cattle, deer, buffalo, rabbits, and sometimes pigs |
Who are the reservoir hosts? | Wildebeest, hartebeest, and sheep! Inapparent infections occur in the reservoirs. |
How is the African form of the virus transmitted? | close contact between cattle and wildebeest via nasal and ocular secretions in a cell-free state |
How is the American form of the virus transmitted? | close contact between cattle and sheep during lambing |
The cattle is a dead-end host. Why? | Cattle have cell-asociated virus, but NOT cell-free virus in secretions so it is NONCONTAGIOUS. |
Virus infection is followed by [?]. Damage to organs and tissues appear to be [?]. | cell-associated viremia. immune-mediated. |
What cells are predominantly associated with widespread necrotizing vasculitis? | CD8+ T Cells |
What gross lesions are observed due to the vascular lesions? | Epithelial erosions, keratoconjunctivitis, and encephalitis |
Morbidity vs. Mortality | low vs. invariably fatal (~100%) |
There is a peracute form of the disease and an acute form. Describe the peractue form. | signs may not show since it only lasts 1-3 days...sever inflammation of the oral and nasal mucosa and hemorrhagic gastroenteritis |
Dsecribe the acute form of the disease. | "zebra striping" in the D. colon. Extensive mucosal erosions of the GIT (bloddy diarrhea). *Bilateral ophthalmia*. Corneal opacity. Edema of the meninges = incoordination, muscle tremors, head pressing |
Is there immunity with this disease? | RARE. Might be immune for life. |
How do you control this virus? | separation of cattle from any resevoir hosts...incidence is too low to justify the development of a vaccine |