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Gammaherpesvirinae

Malignant Catarrhal Fever (MCF)

QuestionAnswer
MCF is sportadic but highly fatal. What tissue does it primarily infect? Lymphoid tissues and epithelial cells of the respiratory and GI tracts
T/F. If there is no wildabeest or sheep contact, there is no need for vaccination. TRUE
Who are the hosts? Cattle, deer, buffalo, rabbits, and sometimes pigs
Who are the reservoir hosts? Wildebeest, hartebeest, and sheep! Inapparent infections occur in the reservoirs.
How is the African form of the virus transmitted? close contact between cattle and wildebeest via nasal and ocular secretions in a cell-free state
How is the American form of the virus transmitted? close contact between cattle and sheep during lambing
The cattle is a dead-end host. Why? Cattle have cell-asociated virus, but NOT cell-free virus in secretions so it is NONCONTAGIOUS.
Virus infection is followed by [?]. Damage to organs and tissues appear to be [?]. cell-associated viremia. immune-mediated.
What cells are predominantly associated with widespread necrotizing vasculitis? CD8+ T Cells
What gross lesions are observed due to the vascular lesions? Epithelial erosions, keratoconjunctivitis, and encephalitis
Morbidity vs. Mortality low vs. invariably fatal (~100%)
There is a peracute form of the disease and an acute form. Describe the peractue form. signs may not show since it only lasts 1-3 days...sever inflammation of the oral and nasal mucosa and hemorrhagic gastroenteritis
Dsecribe the acute form of the disease. "zebra striping" in the D. colon. Extensive mucosal erosions of the GIT (bloddy diarrhea). *Bilateral ophthalmia*. Corneal opacity. Edema of the meninges = incoordination, muscle tremors, head pressing
Is there immunity with this disease? RARE. Might be immune for life.
How do you control this virus? separation of cattle from any resevoir hosts...incidence is too low to justify the development of a vaccine
Created by: lkollmeier