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Alphaherpesvirinae

Marek's Disease

QuestionAnswer
What are four other names for this disease? (1)Fowl paralysis. (2)Range paralysis. (3)Polyneuritis. (4)Neurolymphomatosis
There are four different variations of the serotypes. What are they? Mild, Virulent, Very virulent, and Very virulent plus
Why is a cell-free infectious virus almost impossible to obtain? Only obtained in dander from feather follicles. The virus is slowly cytopathic and remains highly cell associated (macrophage-associated)
How is this HIGHLY CONTAGIOUS disease transmitted? Cell-free virus is released as dander and can survive in house dust and litter for several months. Infection is by inhalation of the contaminated dust or chicken dander.
T/F. Vertical transmission (by egg) has been reported. FALSE
What is the most common pathogenesis? Subclinical infection with virus shedding
There are 3 phases of in vivo infection. What is the first phase? (1)Productive infection:virus replication in the EC of the URT causes a macrophage-associated viremia...virus goes to lymphoid organs and causes a transient productive infection in B cells and B cell cytolysis
What is the second and third phase of the infection? (2)Latent infection: activated T cells and accounts for long-term carrier state. (3)Neoplastic transformation:lesions result from the infiltration and in situ proliferation of the transformed latently infected T lymphocytes
This disease is [?] with overlapping signs. Mortality can reach 80%. PROGRESSIVE
What are the four types of lymphomatosis seen? Neurolymphomatosis, Visceral, Ocular, and Cutaneous
Describe Neurolymphomatosis. [Classial Marek's Disease]. Enlargement of one or more peripheral nerve trunks, show loss of striations, are edematous, gray or yellowish in appearance. UNILATERAL. Lameness, droopy wings, splayed legs, and limberneck.
Describe the ocular type. graying of the iris ("grey eye", "cat's eye", "pearl eye") in one or both eyes due to T Cell infiltration...partial or TOTAL blindness
Describe the cutaneous type. round, nodular lesions in the skin...plucking feathers results in the release of cell-free virus
How do you isolate the virus? Buffy coat or spleen cells
What is the main method of control? VACCINATION...specifically the avirulent turkey herpesvirus vaccine because it infects birds productively
Created by: lkollmeier