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Alphaherpesvirinae
Fading Puppy Syndrome
Question | Answer |
---|---|
What is another name for this disease? | Hemorrhagic Disease of Puppies |
Who is this disease a target of and how do they contract it? | Puppies under 4 weeks of age and they can acquire it in utero, passage through the birth canal, contact with infected littermates, or from oronasal secretions of the dam |
Older dogs get it too. How? | Venereal transmission |
Initial replication of this virus occurs where and then replicates finally in where? | Tonsils and nasal epithelium...then it replicates in endothelial cells |
What is observed in multiple organ systems? | large ecchymotic hemorrhages and necrosis |
How does age affect the outcome of the disease? | Puppies under 1 week of age are susceptible to the fatal, generalized infection while puppies GREATER than 3 weeks of age are generally resistant or show mild signs |
Why are puppies under the age of 1 week a target for this virus? | The CHV-1 virus multiplies best at 33 degrees C. Puppies hypothalamic thermoregulatory systems aren't fully developed until 2-3 weeks, so the temperatures that the puppy is raised in the first 1-2 weeks can help the virus survive or die. |
What are clinical signs seens in puppies? | painful crying, abdominal pain, anorexia, and NO FEVER// Meningoencephalitis occurs in oronasally infected puppies (puppies usually die before CNS signs are shown) |
What clinical signs are seen in older dogs? | Mild rhinitis and pharyngitis along with vaginal or preputial discharge// There is a PERSISTANCE of the virus in the latent form. |
What can you do to control the virus? | There is a lack of vaccines from the low incidence of the severe disease in puppies but reducing hypothermia by using a whelping box or infared lamp helps. Isolation of the infected is also good. |