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Alphaherpesvirinae

Fading Puppy Syndrome

QuestionAnswer
What is another name for this disease? Hemorrhagic Disease of Puppies
Who is this disease a target of and how do they contract it? Puppies under 4 weeks of age and they can acquire it in utero, passage through the birth canal, contact with infected littermates, or from oronasal secretions of the dam
Older dogs get it too. How? Venereal transmission
Initial replication of this virus occurs where and then replicates finally in where? Tonsils and nasal epithelium...then it replicates in endothelial cells
What is observed in multiple organ systems? large ecchymotic hemorrhages and necrosis
How does age affect the outcome of the disease? Puppies under 1 week of age are susceptible to the fatal, generalized infection while puppies GREATER than 3 weeks of age are generally resistant or show mild signs
Why are puppies under the age of 1 week a target for this virus? The CHV-1 virus multiplies best at 33 degrees C. Puppies hypothalamic thermoregulatory systems aren't fully developed until 2-3 weeks, so the temperatures that the puppy is raised in the first 1-2 weeks can help the virus survive or die.
What are clinical signs seens in puppies? painful crying, abdominal pain, anorexia, and NO FEVER// Meningoencephalitis occurs in oronasally infected puppies (puppies usually die before CNS signs are shown)
What clinical signs are seen in older dogs? Mild rhinitis and pharyngitis along with vaginal or preputial discharge// There is a PERSISTANCE of the virus in the latent form.
What can you do to control the virus? There is a lack of vaccines from the low incidence of the severe disease in puppies but reducing hypothermia by using a whelping box or infared lamp helps. Isolation of the infected is also good.
Created by: lkollmeier