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Equine Herpesvirus 1

This is the MOST VIRULENT equine herepesvirus and is associated with what four things? "ABORTION STORM". Respiratory disease. Perinatal foal disease. Encephalitis
T/F. It is the second most important cause of viral abortion in horses. FALSE! It IS THE MOST important cause of viral abortion in horses.
How is this virus transmitted?1 Inhalation of infected aerosols, direct or indirect contact with nasal discharges, aborted fetuses, placenta or fluids
After inhalation, where does the virus go? Replicates in the epithelial cells of the respiratory tract and localizes in regional lnn.
What two things does this virus have a predilection site for? Circulating leukocytes and Endothelial cells
This virus causes immunosuppresion. How? It codes for a protein that inhibits TAP protein so the antigen cannot be delivered and present to class I MHC molecules in the ER
What pathogenesis is seen in a pregnant mare? Macrophage-associated viremia which results in abortion
When do most abortions occur and is reproduction efficiency be compromised? last trimester (between 8th and 10th mo.) and NO, it is not compromised
What can occur as the Primary disease? Neurologic signs (Encephalomyelitis - SOME strains of EHV-1)
What are the neurologic signs characterized by? Vasculitis of the small bv in the CNS -> hypoxic degeneration and hemorrhage throughout the brain and spinal cord
What does this vasculitis result from? Virus-antibody immune complexes...immune complex hypersensitivity
What do the neurologic signs cause in the animal? slight hind limb incoordination to quadriplegia and recumbency resulting in DEATH; Case Fatality 2-3%
What is perinatal foal mortality due to? Interstitial pneumonia
How long-lived is immunity? SHORT, only 2-4 months
Created by: lkollmeier